Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College London, UK.
Acta Obstet Gynecol Scand. 2012 Apr;91(4):458-62. doi: 10.1111/j.1600-0412.2011.01353.x. Epub 2012 Feb 22.
To review the procedure-related complication rates following fetal blood sampling and intrauterine red cell transfusion for anaemic fetuses at a single tertiary center.
A retrospective study of 114 intrauterine transfusions.
A single tertiary referral fetal medicine center at Queen Charlotte's and Chelsea Hospital, Imperial College London, London, UK.
All cases (114) undergoing fetal blood sampling and intrauterine transfusion between January 2003 and May 2010.
Early procedure-related complications (severe fetal bradycardia requiring either abandonment of the procedure or emergency delivery, fetal death, preterm labor or rupture of membranes) were investigated by review of computerized records and individual chart review.
Live birth rate, perinatal mortality, procedure-related fetal bradycardia, preterm labor and procedure-related spontaneous rupture of membranes.
The majority of cases (77.8%) were due to red cell alloimmunization, with anti-D being the commonest cause. The live birth rate was 93.5%, with a procedure-related fetal death rate of 0.9%. The preterm labor rate (<37 weeks' gestation) was 3.5% only occurring in patients undergoing multiple (>3) fetal transfusions. Complications in this series did not appear to be increased the earlier the gestation at which the first transfusion took place.
Despite a reduction in the number of cases requiring intrauterine therapy for fetal anemia, contemporary outcomes appear to be good if not improving. It is important that the experience required to manage these cases should be concentrated in fewer centers to maximize good perinatal outcome.
回顾在伦敦帝国学院夏洛特皇后和切尔西医院的一家三级转诊胎儿医学中心，对贫血胎儿进行胎儿血液采样和宫内输血的相关操作并发症发生率。
对 114 例宫内输血的回顾性研究。
英国伦敦帝国学院夏洛特皇后和切尔西医院的一家三级转诊胎儿医学中心。
2003 年 1 月至 2010 年 5 月期间所有接受胎儿血液采样和宫内输血的病例（114 例）。
通过计算机记录和个别图表审查，调查早期与操作相关的并发症（严重胎儿心动过缓，需要放弃操作或紧急分娩、胎儿死亡、早产或胎膜早破）。
活产率、围产儿死亡率、与操作相关的胎儿心动过缓、早产和与操作相关的自发性胎膜早破。
大多数病例（77.8%）是由于红细胞同种免疫引起的，其中抗-D 是最常见的原因。活产率为 93.5%，与操作相关的胎儿死亡率为 0.9%。早产率（<37 周）仅为 3.5%，仅发生在接受多次（>3 次）胎儿输血的患者中。本系列中的并发症似乎并没有随着首次输血时的胎龄越早而增加。
尽管需要宫内治疗胎儿贫血的病例数量有所减少，但如果不是在改善，当代的结果似乎仍然良好。重要的是，管理这些病例所需的经验应集中在较少的中心，以最大限度地提高良好的围产儿结局。
