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[Extrapyramidal syndrome caused by moderate overdosage of domperidone. Description of a case].

作者信息

Pellegrino M, Sacco M, Lotti F

机构信息

Divisione di Pediatria, Ospedale Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italia.

出版信息

Pediatr Med Chir. 1990 Mar-Apr;12(2):205-6.

PMID:2235667
Abstract

Domperidone is useful in the treatment of vomiting and gastroesophageal reflux in children. Its efficaciousness is due to the antagonist effect on gastrointestinal dopaminergic receptors. Contrary to the initial expectations, domperidone is able to penetrate into the hematoencephalic barrier and to cause adverse neurologic reactions. We report a case of extrapyramidal reaction in a child after moderate overdosage of domperidone.

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