Pellegrino M, Sacco M, Lotti F
Divisione di Pediatria, Ospedale Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italia.
Pediatr Med Chir. 1990 Mar-Apr;12(2):205-6.
Domperidone is useful in the treatment of vomiting and gastroesophageal reflux in children. Its efficaciousness is due to the antagonist effect on gastrointestinal dopaminergic receptors. Contrary to the initial expectations, domperidone is able to penetrate into the hematoencephalic barrier and to cause adverse neurologic reactions. We report a case of extrapyramidal reaction in a child after moderate overdosage of domperidone.
多潘立酮可用于治疗儿童呕吐和胃食管反流。其有效性归因于对胃肠道多巴胺能受体的拮抗作用。与最初的预期相反，多潘立酮能够穿透血脑屏障并引起不良神经反应。我们报告一例儿童在中度过量服用多潘立酮后出现锥体外系反应的病例。
