环二肽具有清除自由基的能力。
Cyclic dipeptides exhibit potency for scavenging radicals.
机构信息
Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan.
出版信息
Bioorg Med Chem. 2012 Mar 15;20(6):2002-9. doi: 10.1016/j.bmc.2012.01.050. Epub 2012 Feb 3.
PMID:22356736
Abstract
Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)(·-).
摘要
合成了 20 种含 l-亮氨酸的环二肽，并研究了它们对·OH 和 O(2)(·-)的抗氧化活性。含有极性氨基酸残基的化合物，如 Asp、Cys、Glu、Lys、Pro、Ser 和 Trp，对·OH 的抗氧化活性比维生素 E 高。然而，只有环（l-Cys-l-Leu）能清除 O(2)(·-)。
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