从冷泉来源的橄榄色链霉菌HDN22-001中分离得到的硫代二酮哌嗪衍生物铲霉素A-B和安莎霉素衍生物divergolide X。
The thiodiketopiperazine derivatives shovelmycin A-B and ansamycin derivative divergolide X from the cold-seep-derived Streptomyces olivaceus HDN22-001.
作者信息
Li Chen, Cheng Jiangli, Liu Ruojin, Huang Xiaofei, Zhou Luning, Zhang Guojian, Zhu Tianjiao, Li Dehai, Che Qian
机构信息
School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao, People's Republic of China.
出版信息
J Antibiot (Tokyo). 2025 Apr;78(5):275-280. doi: 10.1038/s41429-025-00812-z. Epub 2025 Mar 4.
Three new compounds including two thiodiketopiperazine derivatives shovelmycins A-B (1-2), and one ansamycin derivative divergolide X (3) were isolated and identified from the culture extract of Streptomyces olivaceus HDN22-001, a marine actinomycete obtained from the deep-sea cold seep sediment sample collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses and ECD calculations. Compound 1 exhibited the strongest DPPH radical scavenging activity with an IC value of 10.83 μM, which was better than that of the positive control vitamin C. And compound 2 was modestly cytotoxic against NCl-H446 cell with the IC value of 26.6 μM.
从南海深海冷泉沉积物样品中分离得到的海洋放线菌橄榄色链霉菌HDN22 - 001的培养提取物中，分离并鉴定出三种新化合物，包括两种硫代二酮哌嗪衍生物——铲霉素A - B（1 - 2）和一种安莎霉素衍生物——地弗戈利德X（3）。通过光谱分析和ECD计算确定了它们的结构和绝对构型。化合物1表现出最强的DPPH自由基清除活性，IC值为10.83 μM，优于阳性对照维生素C。化合物2对NCl - H446细胞具有中等程度的细胞毒性，IC值为26.6 μM。
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