Department of Psychiatry, St. Martin De Porres Hospital, Chiayi, Taiwan.
Eur Neuropsychopharmacol. 2012 Sep;22(9):641-6. doi: 10.1016/j.euroneuro.2012.01.009. Epub 2012 Feb 21.
Most common psychiatric diseases have been found to be associated with disturbance of both the hypothalamic-pituitary-adrenal (HPA) axis and the brain serotonergic system. The aim of this study was to explore the neuroendocrine relationships between the dexamethasone suppression test (DST) and serotonin transporter (SERT) availability in healthy volunteers. Sixty-six participants (30 males and 36 females) were recruited from the community. The DST suppression rate (D%) is the reduction in cortisol level from Day 1 (D1) to Day 2 (D2) in proportion to the Day 1 cortisol level (D%=(D1-D2)/D1×100%). SPECT with [(123)I] ADAM was used to measure SERT availability. A significant correlation between D% and SERT availability was noted in all subjects (Spearman's ρ=0.26, p=0.03) and in the male subjects (Spearman's ρ=0.41, p=0.02). SERT availability may be sensitive to changes in DST, especially in males.
大多数常见的精神疾病都与下丘脑-垂体-肾上腺（HPA）轴和脑 5-羟色胺能系统的紊乱有关。本研究旨在探索健康志愿者中地塞米松抑制试验（DST）和 5-羟色胺转运体（SERT）可利用度之间的神经内分泌关系。从社区招募了 66 名参与者（30 名男性和 36 名女性）。DST 抑制率（D%）是 D1 到 D2 日的皮质醇水平相对于 D1 日皮质醇水平的降低（D%=（D1-D2）/D1×100%）。使用 SPECT 与 [(123)I]ADAM 测量 SERT 可利用度。所有受试者（Spearman's ρ=0.26，p=0.03）和男性受试者（Spearman's ρ=0.41，p=0.02）均注意到 D%与 SERT 可利用度之间存在显著相关性。SERT 可利用度可能对 DST 的变化敏感，尤其是在男性中。
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