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5-羟色胺转运体可用性与海洛因使用者复发时间的相关性:一项双同位素 SPECT 小样本试点研究。

The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study.

机构信息

Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

出版信息

Eur Neuropsychopharmacol. 2012 Sep;22(9):647-50. doi: 10.1016/j.euroneuro.2012.01.002. Epub 2012 Feb 13.

Abstract

Neuroimaging evidence supporting an association between either dopamine or serotonin and time to relapse of heroin users is limited. In this two-isotope SPECT small sample (N=9) pilot study, the relationship between the availability of serotonin transporter (SERT) and dopamine transporter (DAT) and the relapse of heroin users was investigated. A significant negative association between SERT availability and time to relapse among those who relapsed (N=7) was found.

摘要

神经影像学证据支持多巴胺或 5-羟色胺与海洛因使用者复吸时间之间存在关联,但相关证据有限。在这项使用两种放射性同位素 SPECT 的小样本(N=9)初步研究中,研究人员调查了 5-羟色胺转运体(SERT)和多巴胺转运体(DAT)的可用性与海洛因使用者复吸之间的关系。结果发现,在复吸者(N=7)中,SERT 可用性与复吸时间之间存在显著负相关。

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