Department of Urology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Curr Opin Urol. 2012 May;22(3):237-42. doi: 10.1097/MOU.0b013e328351dcb1.
Active surveillance is emerging as a serious alternative to radical therapy for low-risk prostate cancer. In a situation in which the difference in effects on disease morbidity and mortality of different treatment options for these malignancies is likely to be small, the quality of life and psychological aspects may be decisive in treatment choice.
The following three are the main issues being covered in the literature on psychological aspects of active surveillance. First, the process of consultation with the physician and treatment choice in men diagnosed with low-risk prostate cancer. Second, the effect of active surveillance on physical domains and resulting anxiety and distress, and on quality of life in general. And third, the possible supportive and educational interventions for patients on active surveillance. Observations are scarce and derived from nonrandomized studies with a limited follow-up after diagnosis.
At the moment of treatment choice, fear of disease progression is the main reason to reject active surveillance. Active surveillance may spare physical domains and does not cause much anxiety or distress on short term in men who choose this strategy. Once men opt for active surveillance, only a minority of them switch to radical treatment due to psychological reasons. Supportive and educational interventions should be considered.
主动监测作为低危前列腺癌根治性治疗的替代方法正在兴起。在这些恶性肿瘤的不同治疗方案对疾病发病率和死亡率影响可能很小的情况下,生活质量和心理方面可能是治疗选择的决定性因素。
文献中主要涉及主动监测的心理方面的三个问题。首先,对低危前列腺癌诊断的男性进行医生咨询和治疗选择的过程。其次,主动监测对身体方面的影响以及由此产生的焦虑和痛苦,以及对一般生活质量的影响。第三,对接受主动监测的患者进行可能的支持和教育干预。这些观察结果很少,并且来自非随机研究,在诊断后随访时间有限。
在治疗选择时,对疾病进展的恐惧是拒绝主动监测的主要原因。主动监测可能会避免身体方面的问题,并且对于选择这种策略的男性来说,在短期内不会引起太多的焦虑或痛苦。一旦男性选择主动监测,由于心理原因,只有少数人会转为根治性治疗。应考虑支持和教育干预。