Huang Dan-Lin, Yi Zhu-Wen
Department of Pediatrics, Second Xiangya Hospital of Central South University, Changsha, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Feb;14(2):154-60.
This paper summarizes the current literature on the potential therapeutic role of stem cell transplantation for kidney injury and repair and focuses on the choice of types of stem cells, the method of transplantation, and the mechanisms of stem cell homing to injured renal tissues and its protective effects. The application of umbilical cord mesenchymal stem cells (UC-MSCs) shows wide prospects, but the approach and optimal dose of cell transplantation are under intensive investigation. Signals that regulate stem cell homing to injured renal tissues may be related to chemokines or factors released in the target site. Several studies have pointed out that paracrine and endocrine of stem cells are the most likely mechanism of action in the injured nephron. Many questions remain unanswered but stem cell-based therapy is a promising new strategy for acute and chronic kidney diseases.
本文总结了目前关于干细胞移植在肾脏损伤修复中的潜在治疗作用的文献，并重点关注干细胞类型的选择、移植方法以及干细胞归巢至损伤肾组织的机制及其保护作用。脐带间充质干细胞（UC-MSCs）的应用显示出广阔前景，但细胞移植的方法和最佳剂量仍在深入研究中。调节干细胞归巢至损伤肾组织的信号可能与靶位点释放的趋化因子或因子有关。多项研究指出，干细胞的旁分泌和内分泌作用是损伤肾单位中最可能的作用机制。许多问题仍未得到解答，但基于干细胞的治疗是治疗急慢性肾脏疾病的一种有前景的新策略。
