Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
J Urol. 2010 Jul;184(1):26-33. doi: 10.1016/j.juro.2010.03.050. Epub 2010 May 15.
The potential use of stem cells for acute and chronic renal injury is under intensive investigation. We summarized the current literature on the potential therapeutic role of mesenchymal stem cells for kidney injury.
We reviewed the pertinent literature on mesenchymal stem cell therapy for acute and chronic renal injury.
Experimental evidence suggests that administering exogenous mesenchymal stem cells during acute and chronic kidney injury may improve functional and structural recovery of the tubular, glomerular and interstitial kidney compartments. Several studies point to a paracrine and/or endocrine mechanism of action rather than to direct repopulation of cells in the injured nephron. Multiple questions remain unanswered regarding the protective action of mesenchymal stem cells during renal injury, including signals that regulate stem cell homing to injured tissue, factors regulating paracrine and/or endocrine activity of exogenous mesenchymal stem cells and particularly the long-term behavior of administered stem cells in vivo.
Many questions remain unanswered but mesenchymal stem cell based therapy is a promising new strategy for acute and chronic kidney disease.
干细胞在急性和慢性肾损伤中的潜在应用正在受到深入研究。我们总结了间充质干细胞治疗肾脏损伤的潜在治疗作用的相关文献。
我们回顾了有关间充质干细胞治疗急性和慢性肾损伤的相关文献。
实验证据表明，在急性和慢性肾损伤期间给予外源性间充质干细胞可能改善肾小管、肾小球和肾间质的功能和结构恢复。有几项研究指出，其作用机制是旁分泌和/或内分泌，而不是直接再生成损伤肾单位的细胞。在肾损伤过程中，间充质干细胞的保护作用仍有许多问题尚未得到解答，包括调节干细胞归巢到损伤组织的信号、调节外源性间充质干细胞旁分泌和/或内分泌活性的因素，以及特别是给予的干细胞在体内的长期行为。
尽管仍有许多问题尚未得到解答，但基于间充质干细胞的治疗是急性和慢性肾脏病的一种很有前途的新策略。
