Katsenos Stamatis, Psara Anthoula, Panagou Chara
Department of Pneumonology, Army General Hospital of Athens, Athens, Greece.
J Oncol Pharm Pract. 2013 Mar;19(1):93-4. doi: 10.1177/1078155212438453. Epub 2012 Feb 22.
Pemetrexed is indicated for locally advanced or metastatic non-squamous non-small-cell lung cancer as an initial treatment in combination with cisplatin or after prior chemotherapy as a single agent. It is generally a well-tolerated drug. The most common adverse reactions (incidence ≥ 20%) with single-agent use are fatigue, nausea, and anorexia. Additional common side effects when used in combination with cisplatin include vomiting, neutropenia, leukopenia, anemia, stomatitis/pharyngitis, thrombocytopenia, and constipation. Peripheral edema with associated erythema has rarely been described as an adverse effect. Herein, we report a patient with advanced non-small-cell lung cancer who experienced bilateral peripheral edema after pemetrexed administration. Discontinuation of pemetrexed and corticosteroids use completely resolved peripheral edema.
培美曲塞适用于局部晚期或转移性非鳞状非小细胞肺癌，作为初始治疗与顺铂联合使用，或在先前化疗后作为单药使用。它通常是一种耐受性良好的药物。单药使用时最常见的不良反应（发生率≥20%）是疲劳、恶心和厌食。与顺铂联合使用时的其他常见副作用包括呕吐、中性粒细胞减少、白细胞减少、贫血、口腔炎/咽炎、血小板减少和便秘。伴有红斑的外周水肿很少被描述为不良反应。在此，我们报告一名晚期非小细胞肺癌患者，在使用培美曲塞后出现双侧外周水肿。停用培美曲塞和使用皮质类固醇后，外周水肿完全消退。
