Key Laboratory of Gene Engineering of the Ministry of Education, College of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Metallomics. 2012 Mar;4(3):239-43. doi: 10.1039/c2mt00180b. Epub 2012 Feb 23.
Helicobacter pylori causes various gastric diseases, such as gastritis, peptic ulcerations and gastric cancer. Bismuth-based triple or quadruple therapies have been commonly recommended for the treatment of H. pylori infections. Up to now, the molecular mechanisms by which bismuth inhibits the growth of H. pylori are far from clear. The present concise review intends to cover the most recent reports and discoveries in the field of the inhibitory mechanism of bismuth against H. pylori as well as the bacterial protective response to drug treatment, which will help us to further understand the molecular mechanisms underlying the actions of metal-based drugs and stimulate further development of effective anti-bacterial drugs.
幽门螺杆菌可引起多种胃部疾病，如胃炎、消化性溃疡和胃癌。含铋三联或四联疗法已被广泛推荐用于治疗幽门螺杆菌感染。迄今为止，铋抑制幽门螺杆菌生长的分子机制仍不清楚。本综述旨在涵盖有关铋抑制幽门螺杆菌的抑制机制以及细菌对药物治疗的保护反应的最新报告和发现，这将有助于我们进一步了解基于金属药物作用的分子机制，并激发有效抗菌药物的进一步开发。
