Isobolographic Analysis Laboratory, Institute of Agricultural Medicine, Lublin, Jaczewskiego 2, PL 20-090 Poland.
Pharmacol Rep. 2011;63(6):1316-23. doi: 10.1016/s1734-1140(11)70696-x.
Dentate granule cell neurogenesis persists throughout life in the hippocampus of mammals. Alterations in this process occur in many neurological diseases, including epilepsy. Among the different types of epilepsy, the most frequent is temporal lobe epilepsy (TLE). Therefore, a number of laboratory studies use animal models of TLE to observe the fate of neuronal cells after seizures. Hippocampal neurogenesis is very sensitive to physiological and pathological stimuli. Seizures, as pathological stimuli, alter both the extent and the pattern of neurogenesis, which is associated with cognitive function. Various alterations in neurogenesis are observed depending on the amount of time that has elapsed after the seizures. In acute seizures, neurogenesis generally increases, whereas in chronic epilepsy, neurogenesis decreases. Moreover, several methods currently used for the treatment of brain disorders such as TLE can also have significant impacts on cognitive functions. This review is focused on the recent findings regarding neurogenesis in animal models of TLE.
在哺乳动物的海马体中，颗粒细胞神经发生贯穿一生。这一过程的改变发生在许多神经疾病中，包括癫痫。在不同类型的癫痫中，最常见的是颞叶癫痫（TLE）。因此，许多实验室研究使用 TLE 的动物模型来观察癫痫发作后神经元细胞的命运。海马神经发生对生理和病理刺激非常敏感。癫痫发作作为病理刺激，改变了神经发生的程度和模式，这与认知功能有关。根据癫痫发作后时间的长短，观察到各种不同的神经发生改变。在急性癫痫发作中，神经发生通常增加，而在慢性癫痫中，神经发生减少。此外，目前用于治疗 TLE 等脑部疾病的几种方法也可能对认知功能产生重大影响。这篇综述重点介绍了 TLE 动物模型中神经发生的最新发现。
