Tammi M, Rönnemaa T, Vihersaari T, Lehtonen A, Viikari J
Atherosclerosis. 1979 Jan;32(1):23-32. doi: 10.1016/0021-9150(79)90143-6.
The effect of sera from normolipidemic men engaging in normal physical activity and from high density lipoproteinemic lumberjacks engaging in vigorous physical activity on the incorporation of [3H]thymidine and the synthesis of glycosaminoglycans by human aortic smooth muscle cells in culture was measured. At high concentration (15%) high density lipoproteinemic serum inhibited significantly (P less than 0.001) the incorporation of thymidine. The serum inhibited the synthesis of glycosaminoglycans at all concentrations tested (1--15%) with the most marked inhibition at 10 and 15%. At lower concentrations (1--5%) the inhibition was more pronounced for sulphated glycosaminoglycans than for hyaluronic acid. The inhibition was of the same magnitude for the subclasses (chondroitin, dermatan and heparan sulphates) of sulphated glycosaminoglycans studied. High density lipoproteinemia due to vigorous physical work is postulated as a protective factor against the early biochemical reactions of arterial smooth muscle cells in the development of atherosclerosis.
检测了从事正常体力活动的血脂正常男性血清以及从事剧烈体力活动的高密度脂蛋白血症伐木工血清，对培养的人主动脉平滑肌细胞掺入[3H]胸腺嘧啶核苷及糖胺聚糖合成的影响。在高浓度（15%）时，高密度脂蛋白血症血清显著抑制（P小于0.001）胸腺嘧啶核苷的掺入。在所有测试浓度（1% - 15%）下，该血清均抑制糖胺聚糖的合成，在10%和15%时抑制最为明显。在较低浓度（1% - 5%）时，对硫酸化糖胺聚糖的抑制比对透明质酸更显著。所研究的硫酸化糖胺聚糖亚类（软骨素、硫酸皮肤素和硫酸乙酰肝素）的抑制程度相同。剧烈体力劳动导致的高密度脂蛋白血症被认为是动脉粥样硬化发展过程中针对动脉平滑肌细胞早期生化反应的一种保护因素。
