Figueiró-Filho Ernesto Antonio, Oliveira Vanessa Marcon de, Coelho Lílian Rezende, Breda Ili
Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
Rev Bras Ginecol Obstet. 2012 Jan;34(1):40-6. doi: 10.1590/s0100-72032012000100008.
To determine the frequency and the association of serum markers for inherited and acquired thrombophilias in pregnant women with a history of severe pre-eclampsia in previous pregnancies.
Case-control study consisting of 81 pregnant women with a history of severe pre-eclampsia in previous pregnancies (study group) and 32 women with no history of severe pre-eclampsia in previous pregnancies (control group). The presence of inherited thrombophilia and antiphospholipid antibodies was screened in both groups. We used the chi-square test with Yates correction to assess associations and calculate the relative risks.
The presence of thrombophilia was detected in 60.0% of patients with a previous history of pre-eclampsia and in 6.0% of the control patients. A significant association was found between pre-eclampsia in a previous pregnancy and the presence of markers for hereditary thrombophilia/antiphospholipid antibodies (p<0.05). The relative risk to develop pre-eclampsia was found to be 1.57 (1.34<RR<1.84) for pregnant women with antiphospholipid antibodies, 1.53 (1.26<RR<1.86) for women with hereditary thrombophilia markers and 1.86 (1.45<RR<2.38) considering the presence of hereditary thrombophilia and/or antiphospholipid antibodies.
Women with serum markers for inherited or acquired thrombophilia showed a high relative risk to develop pre-eclampsia.
确定有重度子痫前期既往史的孕妇中遗传性和获得性易栓症血清标志物的频率及相关性。
病例对照研究，包括81例有重度子痫前期既往史的孕妇（研究组）和32例无重度子痫前期既往史的孕妇（对照组）。两组均筛查遗传性易栓症和抗磷脂抗体的存在情况。我们使用校正Yates检验来评估相关性并计算相对风险。
有子痫前期既往史的患者中60.0%检测到易栓症，对照组患者中6.0%检测到易栓症。既往子痫前期与遗传性易栓症/抗磷脂抗体标志物的存在之间存在显著相关性（p<0.05）。发现抗磷脂抗体阳性的孕妇发生子痫前期的相对风险为1.57（1.34<RR<1.84），有遗传性易栓症标志物的女性为1.53（1.26<RR<1.86），考虑遗传性易栓症和/或抗磷脂抗体的存在时为1.86（1.45<RR<2.38）。
有遗传性或获得性易栓症血清标志物的女性发生子痫前期的相对风险较高。
