[2000 - 2009年古巴抗结核药物耐药性监测]
[Surveillance of resistance to antitubercular drugs in Cuba, 2000-2009].
作者信息
Montoro Ernesto, Lemus Dihadenys, Echemendia Miguel, Diaz Raúl, Mederos Lilian, Martinez Maria Rosarys, Llop Alina, Llanes Maria Josefa
机构信息
Laboratorio Nacional de Referencia e Investigaciones en Tuberculosis y Micobacterias, Centro Colaborador de la OPS/OMS, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba.
出版信息
Rev Panam Salud Publica. 2011 Dec;30(6):615-8. doi: 10.1590/s1020-49892011001200020.
OBJECTIVE
Determine the prevalence of resistance to antitubercular drugs in Cuba in the 2000-2009 decade.
METHODS
A prospective longitudinal study was conducted. The sample group consisted of 2,285 Mycobacterium tuberculosis isolates obtained from throughout the country in the period from 1 January 2000 to 31 December 2009. The proportion method was used in Löwenstein-Jensen media with the first-line drugs: isoniazid, streptomycin, ethambutol, and rifampicin.
RESULTS
In the new cases and patients with a history of previous treatment, resistance was 8.5% and 37.0%, respectively. In these case categories, multidrug resistance was 0.4% and 8.8%, respectively.
CONCLUSIONS
This study shows low prevalence of multidrug-resistant strains in Cuba. The results reflect the progress made by the national control program, which is currently working on the elimination of tuberculosis as a public health problem in the country.
目的
确定2000 - 2009年十年间古巴抗结核药物耐药情况的流行率。
方法
开展了一项前瞻性纵向研究。样本组由2000年1月1日至2009年12月31日期间从全国获取的2285株结核分枝杆菌分离株组成。在罗 - 琴培养基中使用比例法检测一线药物异烟肼、链霉素、乙胺丁醇和利福平。
结果
新发病例和既往有治疗史的患者中，耐药率分别为8.5%和37.0%。在这些病例类别中，多重耐药率分别为0.4%和8.8%。
结论
本研究表明古巴多重耐药菌株的流行率较低。结果反映了国家防控项目所取得的进展，该项目目前正致力于在该国消除结核病这一公共卫生问题。
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