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固定靶肿瘤细胞上人类自体细胞毒性 T 淋巴细胞的扩增。

Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells.

机构信息

RIKEN Cell Bank, The Institute of Physical and Chemical Research (RIKEN) Institute of Applied Biochemistry, Japan.

出版信息

Cytotechnology. 1998 Mar;26(2):119-24. doi: 10.1023/A:1007903614475.

DOI:10.1023/A:1007903614475
PMID:22358549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3466675/
Abstract

Human tumor specific cytotoxic T lymphocytes (CTL) were expanded on formalin-fixed autologous target tumor cells derived from glioblastoma multiforme. Growth response of the CTL restimulated with the fixed target cells was larger than those with live target cells. The results suggest that formalin-fixed tumor cells will be stable sources of tumor antigen for efficient autologous CTL expansion and be useful for adoptive immunotherapy of tumors.

摘要

从多形性胶质母细胞瘤中提取的甲醛固定自体靶肿瘤细胞，可扩增人体肿瘤特异性细胞毒性 T 淋巴细胞（CTL）。用固定靶细胞再刺激 CTL 的生长反应大于用活靶细胞的生长反应。结果表明，甲醛固定的肿瘤细胞将成为肿瘤抗原的稳定来源，用于有效的自体 CTL 扩增，并可用于肿瘤的过继免疫治疗。

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本文引用的文献

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Tumor-specific autologous cytotoxic T lymphocytes from tissue sections.来自组织切片的肿瘤特异性自体细胞毒性T淋巴细胞。
Nat Med. 1996 Dec;2(12):1283. doi: 10.1038/nm1296-1283.
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Regulation of CTLA-4 expression during T cell activation.T细胞激活过程中CTLA-4表达的调控。
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Lysis of human pancreatic adenocarcinoma cells by autologous HLA-class I-restricted cytolytic T-lymphocyte (CTL) clones.人胰腺腺癌细胞被自体 HLA - I 类限制性细胞毒性 T 淋巴细胞（CTL）克隆裂解。
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Induction of human autologous cytotoxic T lymphocytes on formalin-fixed and paraffin-embedded tumour sections.在福尔马林固定石蜡包埋肿瘤切片上诱导人自体细胞毒性T淋巴细胞
Nat Med. 1995 Mar;1(3):267-71. doi: 10.1038/nm0395-267.
5
Generation of cytotoxic T-lymphocytes to a self-peptide/class I complex: a model for peptide-mediated tumor rejection.针对自身肽/MHC I类复合物产生细胞毒性T淋巴细胞：一种肽介导的肿瘤排斥模型。
Cancer Res. 1994 Jan 1;54(1):204-8.
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Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.对患有恶性黑色素瘤的人类体内针对自体肿瘤的特异性细胞溶解免疫反应的鉴定。
J Immunol. 1987 Feb 1;138(3):989-95.
7
Re.: Surface antigen preservation by PLP and formalin fixation and the effects of tissue processing.关于：通过多聚赖氨酸-多聚甲醛（PLP）和福尔马林固定保存表面抗原以及组织处理的影响
J Immunol Methods. 1987 Jan 26;96(1):145. doi: 10.1016/0022-1759(87)90379-6.
8
The detection of endothelial cell antigens in cutaneous tissue using methacarn and periodate lysine paraformaldehyde fixation.使用甲醇卡诺固定液和高碘酸盐赖氨酸多聚甲醛固定法检测皮肤组织中的内皮细胞抗原。
J Immunol Methods. 1986 Jul 11;91(1):45-52. doi: 10.1016/0022-1759(86)90100-6.
9
MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele.肿瘤特异性细胞毒性T细胞对自体黑色素瘤的MHC限制性识别。受显性HLA - A等位基因限制的证据。
J Immunol. 1991 Mar 1;146(5):1692-9.
10
Additive effects of antitumor drugs and lymphokine-activated killer cell cytotoxic activity in tumor cell killing determined by lactate-dehydrogenase-release assay.通过乳酸脱氢酶释放试验测定抗肿瘤药物和淋巴因子激活的杀伤细胞细胞毒活性在杀伤肿瘤细胞中的相加作用。
Cancer Immunol Immunother. 1992;35(4):225-9. doi: 10.1007/BF01789327.