固定靶肿瘤细胞上人类自体细胞毒性 T 淋巴细胞的扩增。
Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells.
机构信息
RIKEN Cell Bank, The Institute of Physical and Chemical Research (RIKEN) Institute of Applied Biochemistry, Japan.
出版信息
Cytotechnology. 1998 Mar;26(2):119-24. doi: 10.1023/A:1007903614475.
Abstract
Human tumor specific cytotoxic T lymphocytes (CTL) were expanded on formalin-fixed autologous target tumor cells derived from glioblastoma multiforme. Growth response of the CTL restimulated with the fixed target cells was larger than those with live target cells. The results suggest that formalin-fixed tumor cells will be stable sources of tumor antigen for efficient autologous CTL expansion and be useful for adoptive immunotherapy of tumors.
摘要
从多形性胶质母细胞瘤中提取的甲醛固定自体靶肿瘤细胞，可扩增人体肿瘤特异性细胞毒性 T 淋巴细胞（CTL）。用固定靶细胞再刺激 CTL 的生长反应大于用活靶细胞的生长反应。结果表明，甲醛固定的肿瘤细胞将成为肿瘤抗原的稳定来源，用于有效的自体 CTL 扩增，并可用于肿瘤的过继免疫治疗。
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