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II 类 MHC 基因的 CG 二核苷酸是突变热点。

CG Dinucleotides of class II MHC genes are mutation hot-spots.

机构信息

Istituto di Chimica Biologica, Università di Ferrara, Italy.

出版信息

Cytotechnology. 1988 Feb;1(2):133-8. doi: 10.1007/BF00146813.

DOI:10.1007/BF00146813
PMID:22358564
Abstract

DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription.

摘要

人类主要组织相容性复合体（MHC）II 类基因的 DNA 甲基化与基因表达以及与甲基化相关的 CG→TG 和 CG→CA 变化相关。研究发现，MHC 类 II 基因的 CG 二核苷酸的胞嘧啶甲基化可能参与产生部分核苷酸多态性，而不是控制转录。

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CG Dinucleotides of class II MHC genes are mutation hot-spots.II 类 MHC 基因的 CG 二核苷酸是突变热点。
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本文引用的文献

1
Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.细胞质斑点杂交。对多个小细胞或组织样本中相对mRNA水平的简单分析。
J Biol Chem. 1982 Aug 10;257(15):8569-72.
2
Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.HLA - DR移植抗原的α链与免疫球蛋白属于同一蛋白质超家族成员。
Cell. 1982 Aug;30(1):153-61. doi: 10.1016/0092-8674(82)90021-6.
3
CG dinucleotide clusters in MHC genes and in 5' demethylated genes.MHC基因和5'去甲基化基因中的CG二核苷酸簇。
Nucleic Acids Res. 1984 May 25;12(10):4385-96. doi: 10.1093/nar/12.10.4385.
4
Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.人类Ⅱ类组织相容性抗原α链基因的同种型和异型变异
Nature. 1984;308(5957):327-33. doi: 10.1038/308327a0.
5
Differential inhibition of HLA-D- or SB-directed secondary lymphoproliferative responses with monoclonal antibodies detecting human Ia-like determinants.用检测人Ia样决定簇的单克隆抗体对HLA - D或SB定向的继发性淋巴细胞增殖反应的差异抑制作用
J Immunol. 1982 Sep;129(3):1070-5.
6
Serologic and immunochemical characterization of the specificity of four monoclonal antibodies to distinct antigenic determinants expressed on subpopulations of human Ia-like antigens.四种单克隆抗体针对人Ia样抗原亚群上表达的不同抗原决定簇的特异性的血清学和免疫化学特征分析。
J Immunol. 1981 Feb;126(2):548-52.
7
Analysis by molecular cloning of the human class II genes.通过分子克隆对人类II类基因进行分析。
Fed Proc. 1984 Dec;43(15):3025-30.
8
Human leukemic K562 cells: suppression of hemoglobin accumulation by a monoclonal antibody to human transferrin receptor.
Biochim Biophys Acta. 1986 Apr 29;886(2):203-13. doi: 10.1016/0167-4889(86)90138-2.