Department of Cell Differentiation, I.S.T., viale Benedetto XVono 10, 16132, GENOVA, (Italy).
Cytotechnology. 1993 Jan;11(Suppl 1):S91-3. doi: 10.1007/BF00746065.
Muscle development is characterized by several cell-recognition events such as the fusion of primary and secondary myoblasts and synaptogenesis. Cell surface adhesion receptors are probably playing an important role in determining the correct evolution of these processes. In this paper we examine the expression of three cell adhesion molecules, N-CAM, N-cadherin and EP-cadherin, duringXenopus larval muscle development. Their differential distribution suggests a specific role for each of these molecules during myogenesis. N-CAM might control the fusion of primary myoblasts as its expression is particularly high in these cells and decreases sharply in myotubes. EP-cadherin is present both in differentiated myotubes and myoblasts and could be involved in secondary myoblast fusion. While N-cadherin appears only much later during muscle differentiation.
肌肉发育的特征是几个细胞识别事件，如原代和次代成肌细胞的融合以及突触形成。细胞表面黏附受体可能在决定这些过程的正确演变中起着重要作用。在本文中，我们研究了三种细胞黏附分子，N-CAM、N-钙粘蛋白和 E-钙粘蛋白，在非洲爪蟾幼虫肌肉发育过程中的表达。它们的差异分布表明这些分子在肌发生过程中具有特定的作用。N-CAM 可能控制原代成肌细胞的融合，因为其表达在这些细胞中特别高，在肌管中急剧下降。E-钙粘蛋白存在于分化的肌管和成肌细胞中，可能参与次代成肌细胞的融合。而 N-钙粘蛋白在肌肉分化过程中仅在稍后出现。
