Modulation of cytotoxic but not genotoxic effects by dicumarol on mitomycin C treated Chinese hamster cells.

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超能文献

作者信息

Fratta D, Rainaldi G, Piras A, Moretti A, Mariani T, Vatteroni L, Simi S, Gervasi P G

机构信息

Istituto di Mutagenesi e Differenziamento, C.N.R., Via Svezia 10, 56124, Pisa, Italy.

出版信息

Cytotechnology. 1991 Feb;5(Suppl 1):86-7. doi: 10.1007/BF00736819.

DOI:10.1007/BF00736819

PMID:22358965

Abstract

摘要

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本文引用的文献

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.由NADPH-细胞色素P-450还原酶和黄嘌呤氧化酶催化的丝裂霉素C及丝裂霉素C代谢物的还原活化作用。

J Biol Chem. 1984 Jan 25;259(2):959-66.

Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.

Biochem Pharmacol. 1989 Nov 15;38(22):4137-43. doi: 10.1016/0006-2952(89)90695-3.

Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.双香豆素对需氧和缺氧小鼠肿瘤细胞中生物还原烷基化剂代谢及细胞毒性的影响

Cancer Res. 1989 Jun 15;49(12):3310-3.

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