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IL-2 induces the release of secondary cytokines which stimulate the cytotoxic activity of either NK or CD8(+) lymphocytes.

作者信息

Testa U, Bulgarini D, Montesoro E, Tritarelli E, Boccoli G, Camagna A, Calabresi F, Peschle C

机构信息

Department of Hematology and Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

出版信息

Cytotechnology. 1991 Feb;5(Suppl 1):126-9. doi: 10.1007/BF00736828.

DOI:10.1007/BF00736828
PMID:22358974
Abstract
摘要

相似文献

1
IL-2 induces the release of secondary cytokines which stimulate the cytotoxic activity of either NK or CD8(+) lymphocytes.白细胞介素-2可诱导次级细胞因子的释放，这些细胞因子会刺激自然杀伤细胞或CD8(+)淋巴细胞的细胞毒性活性。
Cytotechnology. 1991 Feb;5(Suppl 1):126-9. doi: 10.1007/BF00736828.
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Peripheral lymphocytes and intracellular cytokines in C282Y homozygous hemochromatosis patients.C282Y纯合子血色素沉着症患者的外周淋巴细胞和细胞内细胞因子
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Differential development of CD4 and CD8 cytotoxic T cells (CTL) in PBMC across the leprosy spectrum; IL-6 with IFN-gamma or IL-2 generate CTL in multibacillary patients.麻风病谱中PBMC内CD4和CD8细胞毒性T细胞（CTL）的差异发育；白细胞介素-6与干扰素-γ或白细胞介素-2在多菌型患者中产生CTL。
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本文引用的文献

1
Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.淋巴因子激活的杀伤细胞现象。白细胞介素2激活的自体人外周血淋巴细胞对天然杀伤抗性新鲜实体瘤细胞的杀伤作用。
J Exp Med. 1982 Jun 1;155(6):1823-41. doi: 10.1084/jem.155.6.1823.
2
Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients.癌症患者中淋巴因子激活的杀伤细胞和重组白细胞介素-2免疫疗法的血液学效应。
Blood. 1987 Jun;69(6):1654-60.
3
A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone.
关于使用淋巴因子激活的杀伤细胞和白细胞介素-2或单独使用高剂量白细胞介素-2治疗157例晚期癌症患者的进展报告。
N Engl J Med. 1987 Apr 9;316(15):889-97. doi: 10.1056/NEJM198704093161501.
4
Adoptive immunotherapy of cancer using lymphokine activated killer cells and recombinant interleukin-2.利用淋巴因子激活的杀伤细胞和重组白细胞介素-2进行癌症的过继性免疫治疗。
Important Adv Oncol. 1986:55-91.
5
Induction of circulating tumor necrosis factor (TNF alpha) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients.循环肿瘤坏死因子（TNFα）的诱导作为癌症患者对白介素-2（IL-2）发热反应的机制。
J Clin Immunol. 1988 Nov;8(6):426-36. doi: 10.1007/BF00916947.
6
In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2.纯化的人白细胞介素2的体内给药。II. 重组白细胞介素2在体内的半衰期、免疫效应及外周淋巴细胞的扩增
J Immunol. 1985 Oct;135(4):2865-75.
7
Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment.
Cancer Res. 1990 Sep 15;50(18):5795-800.
8
Adoptive immunotherapy with high-dose interleukin-2: kinetics of circulating progenitors correlate with interleukin-6, granulocyte colony-stimulating factor level.高剂量白细胞介素-2的过继性免疫疗法：循环祖细胞动力学与白细胞介素-6、粒细胞集落刺激因子水平相关。
Blood. 1991 Feb 15;77(4):741-9.