Larijani Bagher, Esfahani Ensieh Nasli, Amini Peyvand, Nikbin Behrouz, Alimoghaddam Kamran, Amiri Somayeh, Malekzadeh Reza, Yazdi Nika Mojahed, Ghodsi Maryam, Dowlati Yahya, Sahraian Mohammad Ali, Ghavamzadeh Ardeshir
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Iran.
Acta Med Iran. 2012;50(2):79-96.
Stem cells are undifferentiated cells with the ability of proliferation, regeneration, conversion to differentiated cells and producing various tissues. Stem cells are divided into two categories of embryonic and adult. In another categorization stem cells are divided to Totipotent, Multipotent and Unipotent cells.So far usage of stem cells in treatment of various blood diseases has been studied (such as lymphoblastic leukemia, myeloid leukemia, thalassemia, multiple myeloma and cycle cell anemia). In this paper the goal is evaluation of cell therapy in treatment of Parkinson's disease, Amyotrophic lateral sclerosis, Alzheimer, Stroke, Spinal Cord Injury, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Diabetes, Heart Disease, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases. It should be mentioned that some disease that are the target of cell therapy are discussed in this article.
干细胞是具有增殖、再生、转化为分化细胞以及产生各种组织能力的未分化细胞。干细胞分为胚胎干细胞和成体干细胞两类。在另一种分类中,干细胞被分为全能干细胞、多能干细胞和单能干细胞。到目前为止,已经研究了干细胞在治疗各种血液疾病中的应用(如淋巴细胞白血病、髓细胞白血病、地中海贫血、多发性骨髓瘤和循环细胞贫血)。本文的目的是评估细胞疗法在治疗帕金森病、肌萎缩侧索硬化症、阿尔茨海默病、中风、脊髓损伤、多发性硬化症、放射性肠损伤、炎症性肠病、肝病、杜氏肌营养不良症、糖尿病、心脏病、骨病、肾病、慢性伤口、移植物抗宿主病、败血症和呼吸系统疾病中的应用。应该提到的是,本文讨论了一些作为细胞治疗靶点的疾病。