Department of Biological Science, CHA University, Kyeonggido, Korea.
J Cell Biochem. 2013 Apr;114(4):743-53. doi: 10.1002/jcb.24427.
Due to the limitations of pharmacological and other current therapeutic strategies, stem cell therapies have emerged as promising options for treating many incurable neurologic diseases. A variety of stem cells including pluripotent stem cells (i.e., embryonic stem cells and induced pluripotent stem cells) and multipotent adult stem cells (i.e., fetal brain tissue, neural stem cells, and mesenchymal stem cells from various sources) have been explored as therapeutic options for treating many neurologic diseases, and it is becoming obvious that each type of stem cell has pros and cons as a source for cell therapy. Wise selection of stem cells with regard to the nature and status of neurologic dysfunctions is required to achieve optimal therapeutic efficacy. To this aim, the stem cell-mediated therapeutic efforts on four major neurological diseases, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke, will be introduced, and current problems and future directions will be discussed.
由于药理学和其他当前治疗策略的局限性，干细胞疗法已成为治疗许多无法治愈的神经疾病的有前途的选择。多种干细胞，包括多能干细胞（即胚胎干细胞和诱导多能干细胞）和多能成体干细胞（即胎脑组织、神经干细胞和各种来源的间充质干细胞）已被探索作为治疗许多神经疾病的治疗选择，并且每种类型的干细胞作为细胞治疗的来源都有其优缺点，这一点变得越来越明显。明智地选择与神经功能障碍的性质和状态相关的干细胞对于实现最佳治疗效果是必要的。为此，将介绍干细胞介导的四种主要神经疾病（帕金森病、亨廷顿病、肌萎缩侧索硬化症和中风）的治疗方法，并讨论当前的问题和未来的方向。
