评估糖尿病性和老年性白内障患者血清中的锌水平及晶状体的变化。
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients.
作者信息
Rahim Amena, Iqbal Khadija
机构信息
Department of Biochemistry, Islamic International Medical College, Rawalpindi.
出版信息
J Pak Med Assoc. 2011 Sep;61(9):853-5.
OBJECTIVE
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients
METHODS
A comparative cross sectional study was done at LRBT (Layton Rehmatullah Benevolent Trust) free eye hospital Mandra from July 2010 to August 2010. Twenty Type 2 diabetic patients with cataracts and 20 patients without diabetes of senile cataract were included in the study. Glucose levels were determined by glucose oxidase method and zinc levels measured by colorimeteric method (RANDOX).
RESULTS
The statistical analysis showed a statistically significant decrease in zinc levels in diabetic patients with cataract when compared to individuals with senile cataract (P <0.05). In senile lenses multilayering of cells, wrinkling of the lens capsule, and apoptotic cell death were seen, but in diabetic lenses number of cells decreased and cells were smaller as compared to senile lenses. The results were not statistically significant P >0.05.
CONCLUSION
Our findings in this study show a relationship between zinc deficiency and increased occurrence of cataract among people with diabetes.
目的
评估糖尿病性白内障患者和老年性白内障患者的血清锌水平及晶状体变化
方法
于2010年7月至2010年8月在曼德拉的LRBT（莱顿·雷赫马图拉慈善信托）免费眼科医院进行了一项比较性横断面研究。研究纳入了20例患有白内障的2型糖尿病患者和20例无糖尿病的老年性白内障患者。采用葡萄糖氧化酶法测定血糖水平，用比色法（兰道克斯）测量锌水平。
结果
统计分析表明，与老年性白内障患者相比，糖尿病性白内障患者的锌水平有统计学意义的降低（P<0.05）。在老年性晶状体中可见细胞多层化、晶状体囊膜皱缩和凋亡性细胞死亡，但与老年性晶状体相比，糖尿病性晶状体中的细胞数量减少且细胞较小。结果无统计学意义（P>0.05）。
结论
我们在本研究中的发现表明，锌缺乏与糖尿病患者白内障发生率增加之间存在关联。
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