脂蟾毒配基-佛司可林 C hybrids 的合成及佛司可林生物合成的推测。

Synthesis of a liphagal-frondosin C hybrid and speculation on the biosynthesis of the frondosins.

机构信息

School of Chemistry & Physics, University of Adelaide, North Terrace, Adelaide SA 5005, Australia.

出版信息

Org Lett. 2012 Mar 16;14(6):1524-7. doi: 10.1021/ol300257v. Epub 2012 Feb 24.

Abstract

A hypothesis for the biosynthesis of the frondosins A-E is presented. Synthesis of a liphagal-frondosin C hybrid molecule has been achieved, with the frondosin C 6-7-5-6 ring system being constructed by a photochemical process that follows an intramolecular Paternò-Büchi reaction/fragmentation pathway.

摘要

提出了一个关于 frondosins A-E 生物合成的假设。已经实现了 liphagal-frondosin C 杂种分子的合成，其中 frondosin C 6-7-5-6 环系统是通过遵循分子内 Paternò-Büchi 反应/断裂途径的光化学过程构建的。