Nikolidakis Savvas, Luria David, Weisemberg Jessica Shayovich, Tanami Nechemya, Lev David Bar, Gurevitz Osnat, Sham'a Raed Abu, Eldar Michael, Friedman Paul, Glikson Michael
Leviev Heart Center, Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel.
Pacing Clin Electrophysiol. 2012 May;35(5):586-91. doi: 10.1111/j.1540-8159.2012.03342.x. Epub 2012 Feb 23.
Rate smoothing algorithms, while known to help prevent ventricular tachyarrhythmias in some patients, have been shown to result in underdetection of ventricular tachycardia (VT) due to interaction between bradycardia pacing and tachycardia detection parameters. A new algorithm named Bradycardia Tachycardia Response (BTR) has been developed in order to prevent rate smoothing-induced underdetection. The efficacy of BTR is not known. The aim of this study was to assess the effectiveness of BTR in preventing VT underdetection due to rate smoothing.
Two ICD models (TELIGEN and VITALITY AVT, Boston Scientific, St. Paul, MN, USA) bearing identical rate smoothing algorithms were connected to a VT simulator. Devices were programmed similarly except for the BTR feature that exists in TELIGEN only. The detection performance of both devices was tested using varying combinations of AV delay, rate smoothing down, and upper rate limit and compared between the two models. VT underdetection (delay or nondetection) occurred during pacing in 62% of the VT episodes with VITALITY AVT. In TELIGEN, all simulated VT episodes were detected appropriately as soon as their rates exceeded the programmed VT detection rate. Detection tended to be affected by higher upper rate, longer AV delays, and more aggressive rate smoothing.
The BTR algorithm effectively counteracts VT detection delay caused by the interaction of rate smoothing with VT detection parameters, thus enabling safe use of the rate smoothing feature.
速率平滑算法虽已知有助于预防某些患者的室性快速心律失常,但已表明由于心动过缓起搏与心动过速检测参数之间的相互作用,会导致室性心动过速(VT)检测不足。为防止速率平滑引起的检测不足,已开发出一种名为心动过缓-心动过速反应(BTR)的新算法。BTR的疗效尚不清楚。本研究的目的是评估BTR在预防因速率平滑导致的VT检测不足方面的有效性。
将两种采用相同速率平滑算法的植入式心律转复除颤器(ICD)型号(TELIGEN和VITALITY AVT,美国波士顿科学公司,明尼苏达州圣保罗)连接到VT模拟器。除了仅TELIGEN具备的BTR功能外,两台设备的编程方式相似。使用不同的房室延迟、速率平滑下调和上限频率组合测试两台设备的检测性能,并在两种型号之间进行比较。在VITALITY AVT的62%的VT发作起搏期间出现了VT检测不足(延迟或未检测到)。在TELIGEN中,所有模拟的VT发作一旦其速率超过编程的VT检测速率,都能被适当检测到。检测往往受到较高的上限频率、较长的房室延迟和更激进的速率平滑的影响。
BTR算法有效抵消了速率平滑与VT检测参数相互作用导致的VT检测延迟,从而能够安全使用速率平滑功能。