Uehara Y, Shimizu H, Shimomura Y, Negishi M, Kobayashi I, Kobayashi S
First Department of Internal Medicine, Gunma University Hospital, Maebashi, Japan.
Proc Soc Exp Biol Med. 1990 Nov;195(2):197-201. doi: 10.3181/00379727-195-43134.
The effects of intracerebroventricular injection of recombinant human interleukin 1 beta (rhIL-1 beta), 1 alpha (rhIL-1 alpha), and 2 (rhIL-2) on feeding behavior were examined in previously food-deprived rats for 18 hr. At doses of 2-17 ng/rat, rhIL-1 beta significantly reduced food intake in a dose-dependent manner and the feeding suppression continued about 4 hr later. Only 17 ng/rat rhIL-1 beta reduced body weight gain for 8 hr after the injection. However, rhIL-1 alpha at dose of 17 ng/rat did not show any significant change of food intake and body weight gain during the whole observation period. At both doses of 8 and 40 ng/rat, rhIL-2 also failed to suppress overfeeding after food deprivation. In adrenalectomized rats, feeding suppression by rhIL-1 beta appeared at the 1- to 2-hr time period. The present studies suggest that rhIL-1 beta may be, at least in part, involved in feeding suppression on various inflammatory processes and that adrenal hormones may not play an important role in the induction of feeding suppression by rhIL-1 beta.
在先前禁食18小时的大鼠中，研究了脑室内注射重组人白细胞介素1β（rhIL-1β）、1α（rhIL-1α）和2（rhIL-2）对摄食行为的影响。在剂量为2 - 17 ng/只大鼠时，rhIL-1β以剂量依赖性方式显著降低食物摄入量，并且摄食抑制在约4小时后仍持续。仅17 ng/只大鼠的rhIL-1β在注射后8小时降低体重增加。然而，剂量为17 ng/只大鼠的rhIL-1α在整个观察期内未显示食物摄入量和体重增加有任何显著变化。在8和40 ng/只大鼠这两个剂量下，rhIL-2在食物剥夺后也未能抑制过度摄食。在肾上腺切除的大鼠中，rhIL-1β引起的摄食抑制出现在1至2小时时间段。本研究表明，rhIL-1β可能至少部分参与了对各种炎症过程的摄食抑制，并且肾上腺激素可能在rhIL-1β引起的摄食抑制诱导中不发挥重要作用。
