Duke University School of Medicine, Durham, NC, USA.
Neurol Clin. 2012 May;30(2):621-39. doi: 10.1016/j.ncl.2011.12.012.
Neuromuscular junction (NMJ) disorders may be demonstrated using repetitive nerve stimulation (RNS) testing and single-fiber electromyography (SFEMG). RNS testing with low frequency stimulation reduces the safety factor of neuromuscular transmission (NMT) and may elicit decrementing compound muscle action potential (CMAP) responses. Exercise or tetanic nerve stimulation may potentiate acetylcholine release in presynaptic NMT disorders with CMAP facilitation. SFEMG is a selective recording technique assessing MFAPs within the same motor unit. Jitter is increased in NMJ disorders, and is the temporal variability between these MFAPs. Impulse blocking reflects failure of NMT. RNS and SFEMG findings in NMJ disorders are reviewed.
神经肌肉接头（NMJ）疾病可通过重复神经刺激（RNS）测试和单纤维肌电图（SFEMG）来显示。低频刺激的 RNS 测试降低了神经肌肉传递（NMT）的安全系数，并可能引起递减的复合肌肉动作电位（CMAP）反应。运动或强直神经刺激可增强突触前 NMT 疾病的乙酰胆碱释放，导致 CMAP 易化。SFEMG 是一种选择性记录技术，可评估同一运动单位内的 MFAP。在 NMJ 疾病中，抖动增加，这是这些 MFAP 之间的时间可变性。冲动阻断反映了 NMT 的失败。综述了 NMJ 疾病的 RNS 和 SFEMG 结果。
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