Basel Halil, Kavak Servet, Demir Halit, Meral Ismail, Ekim Hasan, Bektas Hava
Department of Cardiovascular Surgery, Bezmi Alem Foundation University Hospital, İstanbul, Turkey.
Toxicol Ind Health. 2013 Jun;29(5):435-40. doi: 10.1177/0748233712436643. Epub 2012 Feb 23.
This experiment was designed to investigate the effect of levosimendan injection on lipid peroxidation product malondialdehyde (MDA) and antioxidant glutathione (GSH) levels, and activities of antioxidant enzymes in myocardium of rats. Twenty male Wistar-albino rats were divided randomly into 2 study groups, each consisting of 10 rats. The animals in the first group were not treated with drug and served as control. It was found that the MDA and GSH levels decreased in levosimendan injected group. Superoxide dismutase, glutathione peroxidase, catalase and carbonic anhydrase enzyme activities were lower in levosimendan injected group than controls. It was concluded that lower tissue free radical level caused by levosimendan injection led to a lower antioxidant enzymes synthesis in the body and a decrease in the antioxidant enzyme activity and free radical scavenger level in myocardium of rat.
本实验旨在研究左西孟旦注射液对大鼠心肌脂质过氧化产物丙二醛（MDA）、抗氧化剂谷胱甘肽（GSH）水平以及抗氧化酶活性的影响。将20只雄性Wistar白化大鼠随机分为2个研究组，每组10只。第一组动物未接受药物治疗，作为对照组。结果发现，左西孟旦注射组的MDA和GSH水平降低。左西孟旦注射组的超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶和碳酸酐酶活性低于对照组。得出的结论是，左西孟旦注射导致组织自由基水平降低，进而使机体抗氧化酶合成减少，大鼠心肌抗氧化酶活性和自由基清除剂水平下降。
