Remacle J, Houbion A, Alexandre I, Michiels C
Laboratoire de Biochimie Cellulaire, Facultés Universitaires N.D. de la Paix, Namur, Belgique.
Phlebologie. 1990 Apr-Jun;43(2):375-86.
Recent discoveries have shown that venous diseases have a multifactorial etiology. One of the factors which is definitely involved in this pathologic process is the change in the concentration of oxygen. An increase in the concentration of oxygen, hyperoxia, or reoxygenation following hypoxia, damages the tissues by stepping up the production of free radicals. In addition, a reduction in oxygen concentration, or hypoxia, is also damaging, probably through a reduction in ATP synthesis. From a therapeutic standpoint, the veins, and more particularly the endothelium, must be protected against the impact on the tissue of these changes in oxygen concentration. In this study, the effects of Ginkor Fort were tested on cultured endothelial cells subjected to varying oxygen pressures. The results show that Ginkor Fort can provide good protection of endothelial cells against hyperoxia and hypoxia-reoxygenation. These beneficial effects are probably due to the presence of flavonoids in the Ginko biloba extract; these flavonoids have an anti-oxidant effect. In addition, this substance also protects the cells against hypoxia, possibly by increasing the availability of oxygen for ATP synthesis. This dual protective effect, which is produced by two different mechanisms, may account for the wide spectrum of Ginkor Fort in its use in venous diseases.
最近的研究发现表明，静脉疾病具有多因素病因。明确参与这一病理过程的因素之一是氧浓度的变化。氧浓度升高，即高氧，或缺氧后的复氧，会通过加速自由基的产生来损害组织。此外，氧浓度降低，即缺氧，可能也具有损害作用，可能是通过减少ATP合成来实现的。从治疗角度来看，必须保护静脉，尤其是内皮，使其免受这些氧浓度变化对组织的影响。在本研究中，对银杏叶提取物制剂（金纳多）在不同氧压下培养的内皮细胞上的作用进行了测试。结果表明，金纳多能为内皮细胞提供良好的保护，使其免受高氧和缺氧-复氧的影响。这些有益作用可能归因于银杏叶提取物中黄酮类化合物的存在；这些黄酮类化合物具有抗氧化作用。此外，该物质还可能通过增加用于ATP合成的氧的可用性来保护细胞免受缺氧影响。这种由两种不同机制产生的双重保护作用，可能解释了金纳多在静脉疾病治疗中广泛的应用范围。
