Tancer M E, Stein M B, Bessette B B, Uhde T W
Section of Anxiety and Affective Disorders, NIMH, Bethesda, MD 20892.
Physiol Behav. 1990 Jul;48(1):179-81. doi: 10.1016/0031-9384(90)90281-8.
The genetically nervous pointer dog has been proposed as a model for human anxiety disorders. In a double-blind placebo-controlled study, seventeen nervous pointer dogs were treated for four weeks with imipramine hydrochloride (10 mg/kg), a potent antipanic agent in humans. Although three of the dogs demonstrated marked improvement to imipramine but not placebo treatment after short-term administration, chronic imipramine failed to modify the aberrant behavior in any of the dogs. These findings are discussed in the context of the nervous pointer dog as a model for human anxiety disorders.
基因神经性指示犬已被提议作为人类焦虑症的模型。在一项双盲安慰剂对照研究中，17只神经性指示犬接受了为期四周的盐酸丙咪嗪（10毫克/千克）治疗，盐酸丙咪嗪是一种对人类有效的抗惊恐药物。尽管其中三只犬在短期给药后对丙咪嗪而非安慰剂治疗表现出明显改善，但长期使用丙咪嗪未能改变任何一只犬的异常行为。本文在将神经性指示犬作为人类焦虑症模型的背景下对这些发现进行了讨论。
