韩国非离子型造影剂皮肤不良反应的临床研究。

A clinical study of cutaneous adverse reactions to nonionic contrast media in Korea.

作者信息

Jung Kyung Eun, Chung Jimin, Park Byung Cheol, Jee Keum Nahn, Jee Young Koo, Kim Myung Hwa

机构信息

Department of Dermatology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

Ann Dermatol. 2012 Feb;24(1):22-5. doi: 10.5021/ad.2012.24.1.22. Epub 2012 Feb 2.

DOI:10.5021/ad.2012.24.1.22

PMID:22363151

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3283846/

Abstract

BACKGROUND

The use of intravenous contrast media (CM) has increased for the diagnosis of several diseases. The newly developed low osmolar nonionic contrast agents cause significantly decreased adverse reactions than the higher osmolar ones. However, adverse reactions may still occur, ranging in severity from minor side effects to severe complications. However, there have been few reports about cutaneous adverse reactions (CARs) to nonionic monomer CM.

OBJECTIVE

The purpose of this study was to evaluate clinical features of CAR to intravenous nonionic monomer CM.

METHODS

A total 47,338 examinees underwent intravenous iodinated contrast-enhanced computed tomography scan using nonionic monomer CM. Among the adverse reactions to the CM, we divided them into cutaneous or noncutaneous and immediate (<1 hr) or late (≥1 hr) adverse reactions.

RESULTS

Adverse reactions were noted in 62 cases out of the total 47,338 cases; 50 cases (80.7%) were categorized CARs. Among them, there were 24 male and 26 female patients. There was no significant difference between the sexes, and CARs occurred in all age groups. The highest occurrence was in the age range of 50~59 years. CARs included urticaria (78%), angioedema (10%), maculopapular rash (8%), erythema (2%), and pruritus without rash (2%). Immediate reactions were 92% (46 cases), while late reactions were 8% (4 cases).

CONCLUSION

CARs to nonionic monomer CM accounted for most of the adverse reactions (80.7%) and urticaria was the most common.

摘要

背景

静脉内造影剂（CM）在多种疾病诊断中的使用有所增加。新开发的低渗非离子型造影剂引起的不良反应明显少于高渗造影剂。然而，不良反应仍可能发生，严重程度从轻微副作用到严重并发症不等。然而，关于非离子单体CM的皮肤不良反应（CARs）的报道很少。

目的

本研究旨在评估静脉内非离子单体CM的CARs的临床特征。

方法

共有47338名受检者接受了使用非离子单体CM的静脉碘造影增强计算机断层扫描。在对CM的不良反应中，我们将其分为皮肤或非皮肤、即刻（<1小时）或迟发（≥1小时）不良反应。

结果

在47338例总病例中，有62例出现不良反应；50例（80.7%）被归类为CARs。其中，男性24例，女性26例。性别之间无显著差异，所有年龄组均出现CARs。发生率最高的年龄范围是50至59岁。CARs包括荨麻疹（78%）、血管性水肿（10%）、斑丘疹（8%）、红斑（2%）和无皮疹的瘙痒（2%）。即刻反应为92%（46例），迟发反应为8%（4例）。