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网格蛋白装配蛋白 PICALM 是小鼠红系细胞成熟和转铁蛋白内化所必需的。

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.

机构信息

Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women's University, Nara, Japan.

出版信息

PLoS One. 2012;7(2):e31854. doi: 10.1371/journal.pone.0031854. Epub 2012 Feb 21.

DOI:10.1371/journal.pone.0031854
PMID:22363754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3283694/
Abstract

Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal translocation t(10;11)(p13;q14). CALM is sufficient to drive clathrin assembly in vitro on lipid monolayers and regulates clathrin-coated budding and the size and shape of the vesicles at the plasma membrane. However, the physiological role of CALM has yet to be elucidated. Here, the role of CALM in vivo was investigated using CALM-deficient mice. CALM-deficient mice exhibited retarded growth in utero and were dwarfed throughout their shortened life-spans. Moreover, CALM-deficient mice suffered from severe anemia, and the maturation and iron content in erythroid precursors were severely impaired. CALM-deficient erythroid cells and embryonic fibroblasts exhibited impaired clathrin-mediated endocytosis of transferrin. These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice.

摘要

磷酯酰肌醇结合网格蛋白装配蛋白（PICALM），也称为网格蛋白装配淋巴髓性白血病蛋白（CALM），最初作为融合基因 CALM/AF10 的一部分被分离出来，该融合基因源自染色体易位 t(10;11)(p13;q14)。CALM 足以在脂质单层上体外驱动网格蛋白的组装，并调节网格蛋白包被的出芽以及质膜上囊泡的大小和形状。然而，CALM 的生理作用尚未阐明。在这里，使用 CALM 缺陷型小鼠研究了 CALM 在体内的作用。CALM 缺陷型小鼠在子宫内生长迟缓，在整个短暂的生命期间都发育不良。此外，CALM 缺陷型小鼠患有严重的贫血，红系前体细胞的成熟和铁含量严重受损。CALM 缺陷型红细胞和胚胎成纤维细胞表现出转铁蛋白的网格蛋白介导的内吞作用受损。这些结果表明 CALM 是小鼠中红系成熟和转铁蛋白内化所必需的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/a921d45988d6/pone.0031854.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/d9f1bf34f911/pone.0031854.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/fc0a495e1a31/pone.0031854.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/0da9302a98fd/pone.0031854.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/28d7f8971ccf/pone.0031854.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/a921d45988d6/pone.0031854.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/d9f1bf34f911/pone.0031854.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/5272bec85e70/pone.0031854.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/fc0a495e1a31/pone.0031854.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/0da9302a98fd/pone.0031854.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/28d7f8971ccf/pone.0031854.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3bb/3283694/a921d45988d6/pone.0031854.g006.jpg

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