Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Trop Med Int Health. 2012 May;17(5):581-3. doi: 10.1111/j.1365-3156.2012.02961.x. Epub 2012 Feb 26.
Many studies have evaluated the total lymphocyte count (TLC) as a cheap surrogate marker for CD4 cells in HIV-infected patients not receiving antiretroviral therapy (ART). We assessed whether TLC can replace CD4 cell counts in evaluating the immunological response to ART. In a cohort of patients in Indonesia TLC, if measured after at least 1-year ART, correctly identified patients with <200 CD4 cells, and reliably excluded immunological failure, obviating the need for CD4 cell measurement in 43% of patients.
许多研究评估了总淋巴细胞计数（TLC）作为未接受抗逆转录病毒治疗（ART）的 HIV 感染患者 CD4 细胞的廉价替代标志物。我们评估了 TLC 是否可以替代 CD4 细胞计数来评估对 ART 的免疫反应。在印度尼西亚的一个患者队列中，如果在至少接受 1 年 ART 后测量 TLC，可以正确识别出 CD4 细胞<200 的患者，并可靠地排除免疫失败，从而使 43%的患者无需进行 CD4 细胞测量。
