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[移植肾肾动脉狭窄的血管内治疗]

[Endovascular treatment of stenosis of the renal artery in transplanted kidney].

作者信息

Ochoa C, Breda A, Martí J, de La Torre P, Villavicencio H

机构信息

Departamento de Urología, Fundación Puigvert, Barcelona, España.

出版信息

Actas Urol Esp. 2012 May;36(5):325-9. doi: 10.1016/j.acuro.2011.11.013. Epub 2012 Feb 24.

Abstract

INTRODUCTION

The incidence of renal artery stenosis in the transplanted kidney (TRAS) varies between 2 and 23%, being the most frequent vascular complication following renal trasplantation. The delay in diagnosis and treatment can lead to functional graft loss. Percutaneous trasluminal angioplasty with stent (PTAS) is the treatment of choice to restore kidney perfusion.

MATERIALS AND METHODS

Retrospective review of renal transplant casuistic in our institution between September 2005 and August 2009. Were included patients with greater than 70% TRAS and impaired graft function, treated with PTAS. Follow-up at 3, 12 and 36 months was done with creatinine, glomerular filtration rate (GFR) and Doppler ultrasonography (DUS). Technical success was defined as correct stent placement associated with decreased flow, and clinical success as improve renal function during follow-up.

RESULTS

Incidence of TRAS was 7.3% (22/298), 60% PTAS subsidiary. 100% technical success and 84.6% clinical success, 15.4% without changes in renal function. 84% decreases flow rate greater than 70% by DUS, and 26% up to 60%. Wave changes from type III to type II were recorded in 69% and to type I in 33%.

CONCLUSIONS

The PTAS is a safe and effective procedure for the treatment of selected TRAS patients, as it preserves vascular permeability in short and medium term, ensuring the functionality of the graft. DUS is the method of choice for diagnosis and monitoring TRAS.

摘要

引言

移植肾肾动脉狭窄(TRAS)的发生率在2%至23%之间,是肾移植后最常见的血管并发症。诊断和治疗的延迟可导致移植肾功能丧失。经皮腔内血管成形术加支架置入术(PTAS)是恢复肾脏灌注的首选治疗方法。

材料与方法

回顾性分析2005年9月至2009年8月我院肾移植病例。纳入TRAS大于70%且移植肾功能受损并接受PTAS治疗的患者。在3个月、12个月和36个月时进行随访,检查血肌酐、肾小球滤过率(GFR)和多普勒超声(DUS)。技术成功定义为支架正确置入且血流减少,临床成功定义为随访期间肾功能改善。

结果

TRAS发生率为7.3%(22/298),60%接受PTAS辅助治疗。技术成功率为100%,临床成功率为84.6%,15.4%肾功能无变化。DUS显示84%的患者血流速度降低大于70%,26%的患者降低至60%。69%的患者波形从III型转变为II型,33%的患者转变为I型。

结论

PTAS是治疗部分TRAS患者的安全有效方法,因为它在短期和中期可保持血管通透性,确保移植肾的功能。DUS是诊断和监测TRAS的首选方法。

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