Chair of Cardiology, "G. d'Annunzio" University-Chieti, Italy.
Vascul Pharmacol. 2012 Aug 19;57(1):41-7. doi: 10.1016/j.vph.2012.02.005. Epub 2012 Feb 17.
The transcription factor nuclear factor-κB (NF-κB) is a main regulator of the expression of several genes involved in the activation of inflammation, cell proliferation, cell immunity and apoptosis. Excess or inappropriate activation of NF-κB has been observed in human inflammatory diseases, including atherosclerosis. Because of the extensive involvement of NF-κB signaling in human diseases, efforts have been made in developing inhibitors of this pathway. Here we will provide an overview of the biology of NF-κB activation pathways. We will here especially focus on current knowledge of the role of the classical ("canonical") NF-κB activation pathway as a potential therapeutic target for anti-atherosclerotic therapies in clinical applications, and discuss classical and novel therapeutic strategies to reduce its prolonged activation.
转录因子核因子-κB（NF-κB）是参与炎症激活、细胞增殖、细胞免疫和细胞凋亡的几种基因表达的主要调节因子。在人类炎症性疾病中，包括动脉粥样硬化，已经观察到 NF-κB 的过度或不适当激活。由于 NF-κB 信号通路广泛参与人类疾病，因此人们一直在努力开发该途径的抑制剂。在这里，我们将提供 NF-κB 激活途径的生物学概述。我们将特别关注经典（“经典”）NF-κB 激活途径的当前知识，作为临床应用中抗动脉粥样硬化治疗的潜在治疗靶点，并讨论减少其延长激活的经典和新型治疗策略。
