Pediatric Dermatology Unit, University of Padua Via Cesare Battisti 206, IT-35128 Padova, Italy.
Acta Derm Venereol. 2012 Jul;92(4):427-9. doi: 10.2340/00015555-1306.
The aim of this study was to investigate the dermoscopic changes in acquired melanocytic naevi in a large paediatric population over an interval of several years. Images of 717 melanocytic naevi were obtained from 160 consecutive patients. Dermoscopic pigment pattern changes were observed in one of two lesions after a follow-up of one year, in 34 of 295 lesions (11.5%) after 2 years, in 40 of 190 lesions (21.1%) after 3 years, in 40 of 141 lesions (28.4%) after 4 years, in 5 of 37 lesions (13.5%) after 5 years, in 12 of 31 lesions (38.8%) after 6 years, and in 7 of 21 lesions (33.3%) after 7 years. Dermoscopic changes were detected in 25.3% of the lesions in patients aged 3-6 years, in 21% of the lesions in patients aged 7-12 years, and in 15.5% of the lesions in patients over 13 years. Main pattern changes consisted of transition from globular to globular-reticular (35 naevi), from globular to reticular (14 naevi) and from globular-reticular to reticular (24 naevi). These results are consistent with the view that melanocytic naevi generally undergo a characteristic transition from a globular pattern to a reticular pattern. Most of the changes are observed in the 3-6 years age group when hormonal and/or environmental factors are not thought to play a role in pattern alterations.
本研究旨在调查多年间大样本儿童人群获得性黑素细胞痣的皮肤镜变化。从 160 例连续患者中获得了 717 个黑素细胞痣的图像。在一年的随访中，两个病变中有一个观察到皮肤镜色素模式变化，在 295 个病变中有 34 个（11.5%）在 2 年后，在 190 个病变中有 40 个（21.1%）在 3 年后，在 141 个病变中有 40 个（28.4%）在 4 年后，在 37 个病变中有 5 个（13.5%）在 5 年后，在 31 个病变中有 12 个（38.8%）在 6 年后，在 21 个病变中有 7 个（33.3%）在 7 年后。在 3-6 岁的患者中，25.3%的病变出现皮肤镜变化，在 7-12 岁的患者中，21%的病变出现皮肤镜变化，在 13 岁以上的患者中，15.5%的病变出现皮肤镜变化。主要模式变化包括从球状到球状网状（35 个痣）、从球状到网状（14 个痣）和从球状网状到网状（24 个痣）。这些结果与黑素细胞痣通常从球状模式向网状模式转变的观点一致。大多数变化发生在 3-6 岁年龄组，此时激素和/或环境因素被认为不会影响模式改变。
