Song James E, Krunic Aleksandar L
Department of Dermatology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Acta Dermatovenerol Alp Pannonica Adriat. 2011;20(4):207-11.
We report a rare variant of generalized granuloma annulare (GGA) in a 62-year-old male patient. The patient presented with large, annular, violaceous patches on the upper arms and thighs. Histological findings were consistent with interstitial granuloma annulare. In addition, high titers of Epstein-Barr Viral Capsid Antigen (EBV VCA) and EBV Nuclear Antigen (EBVNA) antibodies were found. In-situ hybridization did not reveal EBV RNA in the skin lesions. Immune dysregulation in the setting of chronic EBV infection has been suggested as a contributing factor to the development of this rare variant of GGA.
我们报告了一名62岁男性患者的罕见泛发性环状肉芽肿（GGA）变体。患者上臂和大腿出现大型环状紫红色斑块。组织学检查结果与间质性环状肉芽肿一致。此外，还发现了高滴度的爱泼斯坦-巴尔病毒衣壳抗原（EBV VCA）和EBV核抗原（EBVNA）抗体。原位杂交未在皮肤病变中发现EBV RNA。慢性EBV感染背景下的免疫失调被认为是这种罕见GGA变体发生的一个促成因素。
