Clinical Magnetic Resonance Group, Cancer Research UK and ESPSRC Cancer Imaging Centre, Downs Road, Sutton, Surrey, UK, SM2 5PT.
Eur Radiol. 2012 Jul;22(7):1512-8. doi: 10.1007/s00330-012-2399-0. Epub 2012 Feb 26.
To establish the reproducibility of apparent diffusion coefficient (ADC) measurements in normal fibroglandular breast tissue and to assess variation in ADC values with phase of the menstrual cycle and menopausal status.
Thirty-one volunteers (13 premenopausal, 18 postmenopausal) underwent magnetic resonance twice (interval 11-22 days) using diffusion-weighted MRI. ADC(total) and a perfusion-insensitive ADC(high) (omitting b = 0) were calculated. Reproducibility and inter-observer variability of mean ADC values were assessed. The difference in mean ADC values between the two phases of the menstrual cycle and the postmenopausal breast were evaluated.
ADC(total) and ADC(high) showed good reproducibility (r% = 17.6, 22.4). ADC(high) showed very good inter-observer agreement (kappa = 0.83). The intraclass correlation coefficients (ICC) were 0.93 and 0.91. Mean ADC values were significantly lower in the postmenopausal breast (ADC(total) 1.46 ± 0.3 × 10(-3) mm(2)/s, ADC(high) 1.33 ± 0.3 × 10(-3) mm(2)/s) compared with the premenopausal breast (ADC(total) 1.84 ± 0.26 × 10(-3) mm(2)/s, ADC(high) 1.77 ± 0.26 × 10(-3) mm(2)/s; both P < 0.001). No significant difference was seen in ADC values in relation to menstrual cycle (ADC(total) P = 0.2, ADC(high) P = 0.24) or between postmenopausal women taking or not taking oestrogen supplements (ADC(total) P = 0.6, ADC(high) P = 0.46).
ADC values in fibroglandular breast tissue are reproducible. Lower ADC values within the postmenopausal breast may reduce diffusion-weighted contrast and have implications for accurately detecting tumours.
• ADC values from fibroglandular breast tissue are measured reproducibly by multiple observers. • Mean ADC values were significantly lower in postmenopausal than premenopausal breast tissue. • Mean ADC values did not vary significantly with menstrual cycle. • Low postmenopausal ADC values may hinder tumour detection on DW-MRI.
建立正常纤维腺体乳房组织表观扩散系数（ADC）测量的可重复性，并评估 ADC 值随月经周期阶段和绝经状态的变化。
31 名志愿者（13 名绝经前，18 名绝经后）使用扩散加权 MRI 进行了两次磁共振检查（间隔 11-22 天）。计算了总 ADC（ADC(total)）和无灌注敏感性的 ADC（高 b 值排除，ADC(high)）。评估了平均 ADC 值的重复性和观察者间变异性。评估了月经周期两个阶段和绝经后乳房之间平均 ADC 值的差异。
ADC(total)和 ADC(high)显示出良好的可重复性（r%=17.6%，22.4%）。ADC(high)显示出非常好的观察者间一致性（kappa=0.83）。组内相关系数（ICC）分别为 0.93 和 0.91。绝经后乳房的平均 ADC 值明显低于绝经前乳房（ADC(total)为 1.46±0.3×10(-3)mm(2)/s，ADC(high)为 1.33±0.3×10(-3)mm(2)/s）（均 P<0.001）。ADC 值与月经周期（ADC(total)P=0.2，ADC(high)P=0.24）或绝经后是否服用雌激素补充剂（ADC(total)P=0.6，ADC(high)P=0.46）之间无显著差异。
纤维腺体乳房组织中的 ADC 值是可重复的。绝经后乳房内较低的 ADC 值可能会降低扩散加权对比，对准确检测肿瘤有影响。
多名观察者可重复性测量纤维腺体乳房组织的 ADC 值。
绝经后乳房组织的平均 ADC 值明显低于绝经前乳房组织。
平均 ADC 值与月经周期无显著差异。
绝经后 ADC 值低可能会阻碍 DW-MRI 上肿瘤的检测。
