Jilin Blood Center, Changchun, Jilin 130033, PR China.
Mol Med Rep. 2012 May;5(5):1347-51. doi: 10.3892/mmr.2012.800. Epub 2012 Feb 20.
Human leukocyte antigen (HLA) class II molecule is an integral component of the immune response on which the majority of host genetic studies have concentrated. Many different HLA-II alleles have been demonstrated to play roles in HBV infection. PCR-SSOP methods were applied to determine the HLA-DRB1 genotypes of 769 unrelated healthy individuals from Han Chinese of Northeast China. The frequencies of HLA-DRB109 in hepatitis B virus (HBV)-infected subjects were higher compared to those in the control group. Frequencies of HLA-DRB104 and 13 in the HBV-infected group were significantly lower compared to those in the healthy control group. Frequencies of HLA-DRB112 in the cirrhosis and liver cancer groups were significantly higher than those in the chronic hepatitis B (CHB) patients. The frequency of LA-DRB1*03 in the CHB patient group was significantly higher compared to that in the asymptomatic hepatitis B carrier patients. The above results suggest that the host HLA-II gene is an important factor in the determination of the outcome of HBV infection.
人类白细胞抗原（HLA）II 类分子是免疫反应的一个组成部分，大多数宿主遗传研究都集中在这一点上。许多不同的 HLA-II 等位基因已被证明在乙型肝炎病毒（HBV）感染中发挥作用。应用 PCR-SSOP 方法检测了来自中国东北地区汉族的 769 名无关健康个体的 HLA-DRB1 基因型。与对照组相比，HBV 感染组中 HLA-DRB109 的频率更高。与健康对照组相比，HBV 感染组中 HLA-DRB104 和13 的频率显著降低。肝硬化和肝癌组中 HLA-DRB112 的频率明显高于慢性乙型肝炎（CHB）患者。HBV 感染患者组中 HLA-DRB1*03 的频率明显高于无症状乙型肝炎携带者患者。上述结果表明，宿主 HLA-II 基因是决定 HBV 感染结局的重要因素。
