Boukens Bastiaan J, Christoffels Vincent M
Heart Failure Research Center, Department of Anatomy, Embryology and Physiology, Amsterdam, The Netherlands.
Pediatr Cardiol. 2012 Aug;33(6):900-6. doi: 10.1007/s00246-012-0237-4. Epub 2012 Feb 25.
In the adult heart, electrophysiological heterogeneity is present to guide activation and contraction. A change in electrophysiological heterogeneity, for example, during disease, can contribute to arrhythmogenesis. During development, spatial and temporal patterns of transcriptional activity regulate the localized expression of ion channels that cause electrophysiological heterogeneity throughout the heart. If we gain insight into the regulating processes that generate the electrophysiological characteristics and factors involved during development, we can use this knowledge in the search for new therapeutic targets. In this review, we discuss which factors guide the electrical patterning of atrioventricular conduction system and ventricles and how this patterning relates to arrhythmogenic disease in patients.
在成人心脏中，存在电生理异质性以引导激活和收缩。例如，在疾病期间电生理异质性的改变可导致心律失常的发生。在心脏发育过程中，转录活性的时空模式调节离子通道的局部表达，这些离子通道导致整个心脏的电生理异质性。如果我们深入了解在发育过程中产生电生理特征的调节过程以及所涉及的因素，我们就可以利用这些知识寻找新的治疗靶点。在这篇综述中，我们讨论了哪些因素引导房室传导系统和心室的电活动模式，以及这种模式与患者心律失常性疾病的关系。
