Bernasconi A, Beghetti M
Cardiology Unit, Hôpital des Enfants, Department of Pediatrics, Geneva, Switzerland.
Images Paediatr Cardiol. 2002 Jan;4(1):4-29.
The nitric oxide pathway plays a pivotal, yet diverse, role in human physiology, including modulation of vascular tone, neural transmission and inflammation. Inhaled nitric oxide is a selective pulmonary vasodilator that has emerged rapidly as an important therapeutic agent. It finds its best applications in paediatrics; the use of iNO in term neonates with hypoxaemic respiratory failure, in the assessment of pulmonary vascular reactivity and in the treatment of postoperative pulmonary hypertension in congenital heart disease is well recognised and accepted. This review details the delivery and monitoring aspects of inhaled nitric oxide, its potential toxic and side effects and its applications in several cardiopulmonary disorders in paediatrics.
一氧化氮途径在人体生理学中起着关键而多样的作用，包括调节血管张力、神经传递和炎症。吸入一氧化氮是一种选择性肺血管扩张剂，已迅速成为一种重要的治疗药物。它在儿科领域有最佳应用；吸入一氧化氮用于足月低氧性呼吸衰竭新生儿、评估肺血管反应性以及治疗先天性心脏病术后肺动脉高压，这已得到充分认可和接受。本综述详细介绍了吸入一氧化氮的输送和监测方面、其潜在的毒性和副作用以及在儿科几种心肺疾病中的应用。
