[血清血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）水平与骨肉瘤转移及预后的相关性]

[The correlation between the level of serum VEGF and bFGF with metastasis and prognosis of osteosarcoma].

作者信息

Chen Guo-li, Lin Hai-bin, Wu Xian-wei, Li Rong-yi, Chen Xuan-huang

机构信息

Department of Clinical Medicine, Medical College of Putian University, Putian 351100, China.

出版信息

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Dec;27(12):1343-5.

PMID:22368795

Abstract

AIM

To investigate the correlation between the level of serum VEGF and bFGF with metastasis and re- currence of osteosarcoma.

METHODS

52 patients with osteosarcoma and 60 healthy people as control group were selected. The serum contents of VEGF and bFGF were determined with ELISA before and after operation.

RESULTS

The serum contents of VEGF and bFGF before operation were significantly higher than that in control group ( P < 0.01). The serum contents of VEGF and bFGF after operation descreased significantly but were significantly higher than that in control group(P<0. 01). The serum contents of VEGF and bFGF before operation were positively related to the size of primarily tumor, Enneking type and tumor differentiation(P<0.05). The serum contents of VEGF and bFGF before and after operation were different significantly between recurrence and metastasis positive group with recurrence and metastasis negative group ( P < 0. 01). The Cox proportional hazards model showed that the serum contents of VEGF and bFGF before and after operation were an independent factor of the recurrence and metastasis for osteosar- coma patients after operative ( P <0. 01).

CONCLUSION

The serum contents of VEGF and bFGF before and after operation can offer valuable assessments in evaluation of progression and metastasis prognosis.

摘要

目的

探讨血清血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）水平与骨肉瘤转移及复发的相关性。

方法

选取52例骨肉瘤患者，以60例健康人作为对照组。采用酶联免疫吸附测定法（ELISA）检测手术前后血清VEGF和bFGF含量。

结果

术前血清VEGF和bFGF含量显著高于对照组（P<0.01）。术后血清VEGF和bFGF含量显著降低，但仍显著高于对照组（P<0.01）。术前血清VEGF和bFGF含量与原发肿瘤大小、Enneking分期及肿瘤分化呈正相关（P<0.05）。复发转移阳性组与复发转移阴性组手术前后血清VEGF和bFGF含量差异有统计学意义（P<0.01）。Cox比例风险模型显示，手术前后血清VEGF和bFGF含量是骨肉瘤患者术后复发转移的独立因素（P<0.01）。