Shaheen Iman, Ibrahim Noha
Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt.
Fetal Pediatr Pathol. 2012 Jun;31(3):113-9. doi: 10.3109/15513815.2012.656825. Epub 2012 Feb 27.
Receptor tyrosine kinases, a group of tumor-associated antigens, were introduced as targets for cancer intervention strategies. The human orphan receptor tyrosine kinase-1 (ROR-1) is a member of this family. Overexpression of ROR1 has been reported in B-cell chronic lymphocytic leukemia. The aim of this study was to detect the expression profile of ROR1 in 54 pediatric acute lymphoblastic leukemia (ALL) patients. ROR1 was overexpressed in ALL as the ROR1/ β-actin ratio was higher in ALL children than in control group (P = 0.024). ROR1 is a potential tool for targeted immunotherapy in pediatric ALL patients.
受体酪氨酸激酶是一类肿瘤相关抗原，被作为癌症干预策略的靶点。人类孤儿受体酪氨酸激酶-1（ROR-1）是该家族的成员。据报道，ROR1在B细胞慢性淋巴细胞白血病中过表达。本研究的目的是检测54例儿童急性淋巴细胞白血病（ALL）患者中ROR1的表达情况。ALL中ROR1过表达，因为ALL患儿的ROR1/β-肌动蛋白比值高于对照组（P = 0.024）。ROR1是儿童ALL患者靶向免疫治疗的潜在工具。
