Medical Center of Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Cancer Epidemiol. 2012 Jun;36(3):283-7. doi: 10.1016/j.canep.2011.12.011. Epub 2012 Feb 26.
Glioma is one of the most aggressive human tumors; however, little is known about its genetic risk factors. The role of heredity is likely to be explained by combinations of common low-risk variants. Previous studies have indicated that more than 100 single nucleotide polymorphisms (SNPs) are associated with the risk of glioma.
To further investigate how and to what extent these SNPs contribute to glioma susceptibility in a Chinese population, we analyzed 43 SNPs of 226 glioma patients and 254 normal people in order to evaluate the associations between SNPs and the risk of glioma.
Overall, we found three protective alleles for glioma in patients: the allele "G" of rs1801275 in the IL4R gene by allele model (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.50-0.99; P=0.04) and dominant model (OR, 0.67; 95% CI, 0.46-0.99; P=0.04) analysis respectively, the allele "T" of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23-1.01; P=0.05) analysis, and the allele "G" of rs6470745 in CCDC26 gene by recessive model (OR, 0.48; 95% CI, 0.26-0.89; P=0.02) analysis.
This study provides evidence for three glioma susceptibility genes - TREH, IL4R and CCDC26 - in a Chinese population; this may shed light on molecular markers of glioma susceptibility and could therefore be used as a diagnostic and prognostic marker for glioma patients in clinical study.
神经胶质瘤是最具侵袭性的人类肿瘤之一；然而，人们对其遗传风险因素知之甚少。遗传的作用可能是由常见的低风险变体组合来解释的。先前的研究表明，超过 100 个单核苷酸多态性（SNP）与神经胶质瘤的风险相关。
为了进一步研究这些 SNP 在中国人群中如何以及在多大程度上导致神经胶质瘤易感性，我们分析了 226 例神经胶质瘤患者和 254 例正常人的 43 个 SNP，以评估 SNP 与神经胶质瘤风险之间的关联。
总体而言，我们在患者中发现了三个神经胶质瘤的保护性等位基因：IL4R 基因中 rs1801275 的等位基因“G”，在等位基因模型（比值比 [OR]，0.71；95%置信区间 [CI]，0.50-0.99；P=0.04）和显性模型（OR，0.67；95% CI，0.46-0.99；P=0.04）分析中，TREH 基因中 rs17748 的等位基因“T”，在隐性模型（OR，0.48；95% CI，0.23-1.01；P=0.05）分析中，以及 CCDC26 基因中 rs6470745 的等位基因“G”，在隐性模型（OR，0.48；95% CI，0.26-0.89；P=0.02）分析中。
本研究为中国人群中的三个神经胶质瘤易感性基因——TREH、IL4R 和 CCDC26 提供了证据；这可能为神经胶质瘤易感性的分子标记物提供了启示，并因此可作为神经胶质瘤患者临床研究中的诊断和预后标记物。
