Cheng Yimin, Yang Liting, Shi Guangyao, Chen Peng, Li Liang, Fang Hangrong, Chen Chao
The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China.
The Hospital of Xi'an Shiyou University, Xi'an, People's Republic of China.
Cancer Cell Int. 2021 Jan 4;21(1):1. doi: 10.1186/s12935-020-01646-5.
Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.
Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis.
The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04-2.06, p = 0.028; OR 8.43, 95% CI 1.05-67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.
The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.
子宫内膜癌是女性生殖系统最常见的肿瘤之一。Ninjurin2（NINJ2）是一种新的黏附因子。作为一种血管易感性基因，它在其他癌症中高表达并促进癌细胞生长。我们对NINJ2基因多态性与子宫内膜癌风险进行了关联分析。
对351例子宫内膜癌患者和344例健康对照者进行NINJ2基因的5个单核苷酸多态性（SNP）rs118050317、rs75750647、rs7307242、rs10849390和rs11610368基因分型。采用单因素方差分析检验病例组和对照组的临床指标差异。采用卡方检验比较病例组和对照组的等位基因和基因型频率。通过逻辑回归分析检验比值比（OR）及95%置信区间（95%CI）。
SNP rs118050317突变等位基因C和纯合子CC基因型显著增加子宫内膜癌风险（OR 1.46，95%CI 1.04 - 2.06，p = 0.028；OR 8.43，95%CI 1.05 - 67.89，p = 0.045）。临床指标分析显示，病例组血清中癌胚抗原（CEA）、糖类抗原125（CA125）和甲胎蛋白（AFP）含量显著高于对照组。
NINJ2基因多态性位点rs118050317突变等位基因C与子宫内膜癌风险增加相关。子宫内膜癌患者的CEA、CA125和AFP含量显著更高。
