Post-Graduate Program in Medicine: Medical Science, Universidade Federal do Rio Grande do Sul, Brazil.
Epilepsy Behav. 2012 Mar;23(3):373-6. doi: 10.1016/j.yebeh.2011.12.009. Epub 2012 Feb 26.
In a cross-sectional study, we evaluated the impact of the chronic use of benzodiazepines (BDZ) prescribed for seizure control on the anxiety levels of patients with temporal lobe epilepsy. We assessed the anxiety level of 99 patients with temporal lobe epilepsy with (n=15) or without (n=84) BDZ for seizure control, using the Beck Anxiety Inventory (BAI) or the Hamilton Anxiety Scale (HAMA). Independent risk factors for high anxiety levels were being a female patient (O.R.=2.93; 95% C.I.=1.05-8.16; p=0.039), having uncontrolled seizures (O.R.=4.49; 95% C.I.=1.66-12.11; p=0.003) and having a history of a psychiatric disorder (O.R.=4.46; 95% C.I.=1.63-12.21; p=0.004). However, there were no statistically significant differences in anxiety levels between patients utilizing or not utilizing BDZ prescribed exclusively for seizure control. We concluded that in our study, patients with chronic use of BDZ prescribed exclusively for seizure control showed similar anxiety levels than patients who were not using this class of drug. Additional studies are needed to define better strategies for the treatment of anxiety disorders in epilepsy.
在一项横断面研究中，我们评估了慢性使用苯二氮䓬类药物（BDZ）控制癫痫发作对颞叶癫痫患者焦虑水平的影响。我们使用贝克焦虑量表（BAI）或汉密尔顿焦虑量表（HAMA）评估了 99 例有（n=15）或无（n=84）BDZ 控制癫痫发作的颞叶癫痫患者的焦虑水平。女性患者（O.R.=2.93；95% C.I.=1.05-8.16；p=0.039）、未控制的癫痫发作（O.R.=4.49；95% C.I.=1.66-12.11；p=0.003）和有精神疾病史（O.R.=4.46；95% C.I.=1.63-12.21；p=0.004）是焦虑水平高的独立危险因素。然而，专门用于控制癫痫发作的 BDZ 使用者与非使用者之间的焦虑水平无统计学差异。我们的结论是，在我们的研究中，慢性使用专门用于控制癫痫发作的 BDZ 的患者与未使用此类药物的患者的焦虑水平相似。需要进一步的研究来确定更好的治疗癫痫患者焦虑障碍的策略。
