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随机对照试验的荟萃分析比较了用于李金斯坦腹股沟疝修补术的轻质和重质网片。

Meta-analysis of randomized controlled trials comparing lightweight and heavyweight mesh for Lichtenstein inguinal hernia repair.

机构信息

Barts and The London NHS Trust, Queen Mary's University, West Smithfield, London EC1A 7BE, UK.

出版信息

Hernia. 2012 Oct;16(5):505-18. doi: 10.1007/s10029-012-0901-x. Epub 2012 Feb 28.

Abstract

PURPOSE

Lichtenstein inguinal hernia repair is associated with a low incidence of recurrence; however, the use of heavyweight mesh has been linked with chronic pain and foreign body sensation. It is hypothesized that the use of lightweight mesh may reduce these problems. This study aims to use meta-analysis to compare lightweight and heavyweight mesh for Lichtenstein inguinal hernia repair.

METHODS

Information was gathered from randomized controlled trials that compared lightweight and heavyweight mesh for Lichtenstein inguinal hernia repair. The Cochrane Library, Medline, EMBASE, trial registries, conference proceedings and reference lists were searched. Primary outcome measures were chronic pain, foreign body sensation and hernia recurrence. Secondary outcome measures were duration of surgery, mean visual analogue scale (VAS) pain scores, surgical-site infection, testicular atrophy and haematoma/seroma. The pooled Peto odds ratio (OR) was calculated for categorical data and weighted mean difference (WMD) for continuous data.

RESULTS

Six trials with 1936 hernias were included. Lightweight mesh was associated with reduced chronic pain (OR = 0.67, 95% CI = 0.50-0.90; p < 0.01) and foreign body sensation (OR = 0.43, 95% CI = 0.21-0.93; p < 0.05). Lightweight mesh was also associated with lower VAS pain scores at 3 months after surgery (WMD = -0.35, 95% CI = -0.39 to -0.31; p < 0.0001). There were no differences in hernia recurrence (OR = 1.19, 95% CI = 0.54-2.64; p = 0.66) or other post-operative complications between the two groups.

CONCLUSIONS

The use of lightweight mesh in Lichtenstein inguinal hernia repair is associated with less chronic pain, and foreign body sensation compared with heavyweight mesh without any difference in recurrence.

摘要

目的

Lichtenstein 腹股沟疝修补术的复发率较低;然而,使用重质网片与慢性疼痛和异物感有关。据推测,使用轻质网片可能会减少这些问题。本研究旨在通过荟萃分析比较 Lichtenstein 腹股沟疝修补术中使用轻质和重质网片的效果。

方法

从比较 Lichtenstein 腹股沟疝修补术中使用轻质和重质网片的随机对照试验中收集信息。检索了 Cochrane 图书馆、Medline、EMBASE、试验注册处、会议记录和参考文献列表。主要结局指标为慢性疼痛、异物感和疝复发。次要结局指标为手术持续时间、平均视觉模拟评分(VAS)疼痛评分、手术部位感染、睾丸萎缩和血肿/血清肿。分类数据的汇总 Peto 比值比(OR)和连续数据的加权均数差(WMD)。

结果

纳入了 6 项涉及 1936 例疝的试验。轻质网片与慢性疼痛减轻相关(OR = 0.67,95%CI = 0.50-0.90;p < 0.01)和异物感(OR = 0.43,95%CI = 0.21-0.93;p < 0.05)。轻质网片还与术后 3 个月时的 VAS 疼痛评分较低相关(WMD = -0.35,95%CI = -0.39 至 -0.31;p < 0.0001)。两组之间疝复发率(OR = 1.19,95%CI = 0.54-2.64;p = 0.66)或其他术后并发症无差异。

结论

与重质网片相比,Lichtenstein 腹股沟疝修补术中使用轻质网片与慢性疼痛和异物感减轻相关,但复发率无差异。

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