Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
World J Gastroenterol. 2012 Feb 28;18(8):847-54. doi: 10.3748/wjg.v18.i8.847.
To investigate the association between interleukin (IL)-10-1082 (G/A) promoter polymorphism and acute rejection (AR) in liver transplant (LT) recipients.
Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95% CIs for IL-10-1082 G/A polymorphism and AR were calculated in a fixed- and a random-effects model as appropriate.
This meta-analysis included seven case-control studies, which comprised 652 cases of LT recipients in which 241 cases developed AR and 411 cases did not develop AR. Overall, the variant A allele was not associated with AR risk when compared with the wild-type G allele (OR = 0.94, 95% CI: 0.64-1.39). Moreover, similar results were observed when the AA genotype was compared with the AG/GG genotype (OR = 1.05, 95% CI: 0.55-2.02). When stratifying for ethnicity, no significant association was observed among either Caucasians or Asians. Because only one study was performed in Asian patients, the result of subgroup analysis by ethnicity would not be reliable for Asians. Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. No publication bias was found in the present study.
This meta-analysis suggests that IL-10-1082 G/A polymorphism may be not associated with AR risk in LT recipients among Caucasians.
探讨白细胞介素（IL）-10-1082（G/A）启动子多态性与肝移植（LT）受者急性排斥反应（AR）的关系。
两名研究员独立检索了 Medline、Embase、中国国家知识基础设施和中国生物医学数据库。采用固定效应模型和随机效应模型，分别计算 IL-10-1082 G/A 多态性与 AR 之间的汇总比值比（OR）和 95%置信区间（CI）。
本荟萃分析纳入了 7 项病例对照研究，共包括 652 例 LT 受者，其中 241 例发生 AR，411 例未发生 AR。总体而言，与野生型 G 等位基因相比，变异 A 等位基因与 AR 风险无关（OR=0.94，95%CI：0.64-1.39）。此外，当比较 AA 基因型与 AG/GG 基因型时，也观察到了相似的结果（OR=1.05，95%CI：0.55-2.02）。按种族分层时，在白种人和亚洲人中均未观察到显著相关性。由于仅有一项研究在亚洲患者中进行，因此按种族进行亚组分析的结果对亚洲人来说可能不可靠。将分析仅限于对照处于 Hardy-Weinberg 平衡的研究，结果仍然是一致和稳健的。本研究未发现发表偏倚。
本荟萃分析表明，白细胞介素（IL）-10-1082 G/A 多态性与白种人 LT 受者的 AR 风险无关。
