环孢素 A 治疗的肾病综合征患儿表现出血管舒张功能受损，但无自主神经病变。
Cyclosporine A - treated nephrotic children show impaired vasodilatation but no autonomic neuropathy.
机构信息
Division of Nephrology, Polish Mother's Memorial Hospital Research Institute of Lodz, Poland.
出版信息
Arch Med Sci. 2010 Aug 30;6(4):573-7. doi: 10.5114/aoms.2010.14470. Epub 2010 Sep 7.
INTRODUCTION
The aim of the study was to determine the effect of long-term cyclosporine A (CsA) treatment in children with idiopathic nephrotic syndrome on autonomic nerve function and peripheral blood flow assessed with thermography.
MATERIAL AND METHODS
The study group consisted of 19 nephrotic children treated with cyclosporine A compared to 16 healthy children. The assessment of blood flow was made based on the results of thermographic measurements during the cold stress test by an infrared radiation registering camera. Ewing's battery of non-invasive tests was used to assess autonomic function.
RESULTS
The study showed diminished temperature increase after the cooling test in children with nephrotic syndrome treated with CsA. Sympathetic activity test results were comparable to healthy children.
CONCLUSIONS
It may be hypothesized that cyclosporine A administered even in low doses induces small vessel dysfunction measured by the thermographic method. This effect seems to be independent of sympathetic nervous system involvement, which was absent in cyclosporine A treated nephrotic children.
简介
本研究旨在通过热成像评估自主神经功能和外周血流，确定长期环孢素 A（CsA）治疗特发性肾病综合征儿童的效果。
材料和方法
研究组包括 19 名接受 CsA 治疗的肾病儿童和 16 名健康儿童。血流评估是基于在冷应激试验期间通过红外辐射记录摄像机进行的热成像测量结果得出的。Ewing 电池的非侵入性测试用于评估自主功能。
结果
研究表明，接受 CsA 治疗的肾病综合征儿童在冷却试验后体温升高减少。交感神经活动测试结果与健康儿童相似。
结论
可以假设即使低剂量的环孢素 A 也会引起小血管功能障碍，这可以通过热成像方法测量。这种作用似乎与交感神经系统的参与无关，在接受 CsA 治疗的肾病综合征儿童中并未观察到这种作用。
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