Department of Nuclear Medicine and Oncological Endocrinology, Lodz, Poland.
Arch Med Sci. 2010 Aug 30;6(4):611-6. doi: 10.5114/aoms.2010.14476. Epub 2010 Sep 7.
The influence of demographic and clinical factors on the outcome of (131)I therapy in hyperthyroid patients has been examined, based on a retrospective evaluation of results obtained in patients submitted to (131)I treatment at the Department of Nuclear Medicine and Oncological Endocrinology, Medical University of Lodz (Province Hospital, Zgierz). The goal of the study was to analyse such factors as the age and sex of patients, disease duration, as well as the hormonal status before (131)I application, which could have an influence on the effects of therapy with radioiodine (131)I.
The study involved 500 randomly selected patients with hyperthyroidism, treated with (131)I radioiodine. The following 3 groups were defined: group 1 - patients with multinodular goitre (MNG), n = 200; group 2 - patients with a single autonomous nodule of the thyroid (AFTN), n = 100; group 3 - patients with Graves' disease (GD), n = 200. The local ethics committee (in the Polish Mother's Memorial Hospital - Research Institute, Lodz) approved the study.
The obtained results indicate that the efficacy of therapy with (131)I applied in patients with MNG, AFTN and GD does not depend on either patient sex or patient age. The length of antithyroid treatment before (131)I therapy onset does not appear to have any effect on the therapy outcome, and the baseline thyrotropin concentration seems to be significant only in the case of GD.
The analysed demographic factors do not affect the outcome of (131)I therapy in hyperthyroidism.
本研究回顾性评估了在罗兹医科大学核医学和肿瘤内分泌科（兹格热希医院）接受碘-131 治疗的患者的结果，分析了年龄和性别、疾病持续时间以及碘-131 治疗前的激素状态等因素对放射性碘（131）I 治疗效果的影响。
该研究纳入了 500 名随机选择的甲亢患者，均接受 131I 放射性碘治疗。将患者分为以下 3 组：组 1-多结节性甲状腺肿（MNG）患者，n=200；组 2-甲状腺单个自主性结节（AFTN）患者，n=100；组 3-格雷夫斯病（GD）患者，n=200。当地伦理委员会（波兰母亲纪念医院-研究所以及罗兹）批准了该研究。
研究结果表明，131I 治疗 MNG、AFTN 和 GD 患者的疗效与患者性别或年龄无关。131I 治疗前的抗甲状腺治疗时间似乎对治疗效果没有影响，而基础促甲状腺激素浓度仅在 GD 患者中具有显著意义。
分析的人口统计学因素不会影响甲亢患者 131I 治疗的效果。
